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黄曲霉毒素富集-检测-降解解毒方法的研究进展
张亚平, 单鲁豫, 穆琦瑄, 李文慧, 王丹妮, 王跃飞, 于卉娟
天津中医药大学中医药研究院, 省部共建组分中药国家重点实验室, 天津市中药化学与分析重点实验室, 天津 301617
摘要:
中药在疾病预防治疗中发挥重要作用。随着人们对中药材的需求量不断增大,中药材的使用量日益攀升,其安全性问题备受关注。其中,真菌毒素污染已经成为产业界和科研界关注的焦点问题之一。黄曲霉毒素具有强毒性和致癌性,极易侵染中药材,对中药材质量及临床用药安全构成重大威胁。中药材、饮片、制剂中黄曲霉毒素的检测对保障中药安全性具有重要意义。目前中药中黄曲霉毒素的富集、检测及降解解毒方法报道较多,为了更好地为中药中黄曲霉毒素的研究提供参考,文章综述了近年来关于黄曲霉毒素的富集方法、检测分析技术、降解解毒方法的研究。
关键词:  黄曲霉毒素  富集方法  检测技术  降解解毒
DOI:10.11656/j.issn.1673-9043.2023.05.18
分类号:R284.1
基金项目:国家自然科学基金青年项目(82204769);组分中药国家重点实验室资助项目(QMJJ202102)。
Research progress of aflatoxin enrichment,detection,degradation and detoxification methods
ZHANG Yaping, SHAN Luyu, MU Qixuan, LI Wenhui, WANG Danni, WANG Yuefei, YU Huijuan
Institute of Traditional Chinese Medicine, State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Abstract:
Traditional Chinese medicine(TCM) plays an important role in disease prevention and treatment. With the increasing demand for Chinese medicinal materials,its safety has attracted much attention. Mycotoxin has become one of the focus issues in the field of industry and scientific research. Aflatoxin is highly toxic and carcinogenic,easily infecting Chinese herbal medicines,posing a major threat to the quality of Chinese herbal medicines and the safety of clinical medications. The detection of aflatoxin in Chinese herbal medicines,decoction pieces,and preparations is of great significance to guarantee the safety of Chinese medicines. At present,there are many reports on the methods of enrichment,detection,degradation,and detoxification of aflatoxin in TCM. In order to better provide references for the research of aflatoxin in TCM,this paper reviews the recent research on the enrichment method,detection and analysis technology,degradation,and detoxification method of aflatoxin.
Key words:  aflatoxin  enrichment method  detection technology  detoxification method
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