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| 耳迷走神经电刺激治疗多囊卵巢综合征患者负性情绪的临床观察 |
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张世科1,2, 何慧3, 王宇3, 孙嘉婧4, 莫潇林1, 刘晶1, 于淑雪1, 朱婧锦1, 梁杏1, 高维滨5
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1.深圳市盐田区人民医院康复医学科, 深圳 518081;2.南方科技大学盐田医院康复医学科, 深圳 518081;3.黑龙江中医药大学附属第一医院中医妇科, 哈尔滨 150040;4.黑龙江中医药大学, 哈尔滨 150006;5.黑龙江中医药大学附属第二医院全国名老中医药专家传承工作室, 哈尔滨 150001
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| 摘要: |
| [目的] 观察耳迷走神经电刺激治疗多囊卵巢综合征（PCOS）患者负性情绪的有效性。[方法] 采用随机数字表法将60例PCOS患者随机分为电刺激组和对照组，每组30例。两组患者均于月经第5天接受生活方式干预，电刺激组同时联合使用耳迷走神经电刺激治疗，两组治疗均以1个月为1个疗程，共治疗3个疗程。比较两组患者治疗前后的焦虑自评量表（SAS）评分、抑郁自评量表（SDS）评分、中医症状评分、体质量指数（BMI）、糖代谢指标[空腹胰岛素（FINS）、空腹血糖（FBG），计算稳态模型胰岛素抵抗指数（HOMA-IR）]及炎症因子[血清白细胞介素（IL）-1、IL-6、肿瘤坏死因子-α（TNF-α）]水平。[结果] 与治疗前比较，治疗后电刺激组患者SAS、SDS评分降低，中医症状评分降低，FINS、FBG、HOMA-IR降低，血清IL-1、IL-6和TNF-α水平降低（P<0.05）；对照组中医症状评分降低，FINS、FBG、HOMA-IR降低（P<0.05）。与对照组比较，治疗后电刺激组SAS、SDS评分降低，中医症状评分降低，FINS、FBG、HOMA-IR降低，血清IL-1、IL-6和TNF-α水平降低（P<0.05）。[结论] 在PCOS患者治疗中应用耳迷走神经电刺激，能够有效改善患者焦虑、抑郁状态，还可以改善患者血糖代谢，减轻炎症反应。 |
| 关键词: 耳迷走神经 多囊卵巢综合征 胰岛素抵抗 焦虑 抑郁 |
| DOI：10.11656/j.issn.1673-9043.2024.01.05 |
| 分类号:R711.75 |
| 基金项目:国家自然科学基金项目（81803945）。 |
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| Clinical observation of auricular vagus nerve electrical stimulation in the treatment of negative emotions in patients with polycystic ovary syndrome |
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ZHANG Shike1,2, HE Hui3, WANG Yu3, SUN Jiajing4, MO Xiaolin1, LIU Jing1, YU Shuxue1, ZHU Jingjin1, LIANG Xing1, GAO Weibin5
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1.Department of Rehabilitation Medicine, Yantian District People's Hospital, Shenzhen 518081, China;2.Department of Rehabilitation Medicine, Southern University of Science and Technology Yantian Hospital, Shenzhen 518081, China;3.Gynecology of Traditional Chinese Medicine, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China;4.Heilongjiang University of Chinese Medicine, Harbin 150006, China;5.National Famous Old Chinese Medicine Expert Inheritance Studio, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
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| Abstract: |
| [Objective] To observe the effect of auricular vagus nerve electrical stimulation on negative emotion in patients with polycystic ovary syndrome(PCOS). [Methods] The 60 patients with PCOS were randomly divided into electrical stimulation group and control group, with 30 patients in each group. Both groups received lifestyle intervention on the 5th day of menstruation, and the electrical stimulation group was combined with auricular vagus nerve electrical stimulation. Both groups were treated for 1 month as a course of treatment, with a total of 3 treatments. The scores of self-rating Anxiety Scale(SAS) and self-rating Depression Scale(SDS), as well as traditional Chinese medicine(TCM) medicine symptom score, body mass index(BMI), glucose metabolism index(FINS) and fasting blood glucose(FBG), homeostasis model insulin resistance index(HOMA-IR) and levels of inflammatory factors[serum interleukin 1(IL-1), interleukin 6(IL-6) and tumor necrosis factor α(TNF-α)] before and after treatment were compared between the two groups. [Results] Compared with before treatment, the scores of SAS and SDS, TCM symptom scores, FINS, FBG and HOMA-IR, serum levels of IL-1, IL-6 and TNF-α were decreased in the electrical stimulation group after treatment(P<0.05). In the control group, the scores of TCM symptoms and FINS, FBG and HOMA-IR were decreased(P<0.05). Compared with the control group, the scores of SAS and SDS, TCM symptom scores, FINS, FBG and HOMA-IR, serum levels of IL-1, IL-6 and TNF-α were decreased in the electrical stimulation group after treatment(P<0.05). [Conclusion] The application of auricular vagus nerve electrical stimulation in the treatment of PCOS patients can effectively improve the anxiety and depression, improve blood glucose metabolism and reduce inflammation. |
| Key words: auricular vagus nerve polycystic ovary syndrome insulin resistance anxiety depression |
