头皮针结合体针对急性缺血性卒中患者认知水平及降钙素基因相关肽的影响

Effect of scalp acupuncture combined with body acupuncture in cognitive function of patients with acute ischemic stroke and the related factor of calcitonin gene-related peptide

关键词:  头皮针  急性缺血性脑卒中  认知障碍  降钙素基因相关肽

Key words:  scalp acupuncture  acute ischemic stroke  cognitive impairment  calcitonin gene-related peptide

摘要:

[目的] 确认头皮针结合体针应用对于认知功能与降钙素基因相关肽（CGRP）所产生的影响。[方法] 对于140例患者，使用随机分配方法划分成观察组（70例，脱落10例）以及对照组（70例，脱落8例）。在神经内科基本治疗的基础上，对照组采用体针治疗，体针针刺患侧合谷、外关、三阴交、太冲穴；观察组额外开展头皮针治疗，针刺位置包括顶颞前斜线等，每天进行1次，每周共5次，总计持续治疗2周。对两组进行MMSE评分和血清CGRP测定。[结果] 两组在治疗后90天的MMSE评分和CGRP指标，相对于治疗之前都有显著优化（P<0.05），观察组的数据显著大于对照组（P<0.05）。[结论] 两组治疗均可改善患者认知水平并升高血清CGRP浓度，且观察组疗效优于对照组，其中头皮针结合体针治疗较单纯体针治疗对患者认知水平改善效果更好，该作用可能与血浆CGRP浓度升高有关。

Abstract:

[Objective] To observe the effects of scalp acupuncture combination on cognitive function and calcitonin gene-related peptide(CGRP) in patients with acute ischemic stroke. [Methods] 140 patients with acute ischemic stroke were randomly divided into observation group(70 cases,10 cases dropped off) and control group(70 cases,8 cases dropped off). On the basis of basic treatment in neurology,the control group was treated with body acupuncture,which was used to acupuncture Hegu(LI 4),Waiguan(TE 5),Sanyinjiao(SP 6) and Taichong(LR 3) points on the affected side. The observation group was treated with scalp acupuncture on the basis of the control group. Scalp acupuncture was performed on the anterior oblique line of vertex-temporal(MS 6)(Qianshencong(EX-HN1) to Xuanli(GB 6)),posterior oblique line of vertex-temporal(MS 7)(Baihui(GV 20) to Qubin(GB 7),lower-lateral line of occiput(MS 14),lateral line 2 of vertex(MS9),once a day,5 times a week,for a total of 2 weeks. Mini-mental State Examination(MMSE) score was observed and serum CGRP concentration was detected in two groups. [Results] The MMSE score and CGRP level of the two groups were improved at 90 days after treatment compared with that before treatment(P<0.05),and the MMSE score and CGRP level of the observation group were significantly higher than those of the control group at 90 days after treatment(P<0.05). [Conclusion] The therapeutic effect of the observation group is better than that of the control group,and both groups can improve the cognitive level of patients. Scalp acupuncture combined with body acupuncture has a better effect on the cognitive level of patients than body acupuncture alone,which may be related to the increase of serum CGRP concentration.