| 摘要: |
| 心肌肥厚是心力衰竭等严重不良心血管事件发生发展的独立危险因素。氧化应激能够引起心肌细胞的损伤及纤维化，加速心室重构和心肌肥厚的发展，抑制氧化应激反应能够减缓心肌肥厚的形成，对于预防心力衰竭起到重要作用。作为一条抗氧化应激的经典信号通路，Kelch样环氧氯丙烷相关蛋白-1（Keap1）/核因E2相关因子2（Nrf2）/抗氧化反应元件（ARE）信号通路能够通过激活体内抗氧化应激机制达到减少氧化应激、保护受损心肌、减少心肌细胞纤维化、改善心肌肥厚的作用。文章旨在总结中医药通过调控Keap1/Nrf2/ARE信号通路改善心肌肥厚的研究进展，为中医药改善心肌肥厚提供思路。 |
| 关键词: 中医药 心肌肥厚 氧化应激 |
| DOI：10.11656/j.issn.1673-9043.2024.02.12 |
| 分类号:R285；R542.2 |
| 基金项目:国家自然科学基金项目（82274437）；国家中医药管理局中医药创新团队及人才支持计划项目（ZYYCXTD-C-202203）；天津市卫健委中医药重点领域科技项目（2022009）；天津中医药大学第一附属医院拓新工程科研基金项目（院ZD202108）。 |
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| Research progress of traditional Chinese medicine in the treatment of myocardial hypertrophy by regulating Keap1/Nrf2/ARE signaling pathway |
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ZHANG Yongbo1,2,3, BI Yingfei1,2
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1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China;2.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China;3.Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Cardiac hypertrophy is an independent risk factor for the occurrence and development of severe adverse cardiovascular events such as heart failure. Oxidative stress can cause myocardial cell damage and fibrosis,accelerate the development of ventricular remodeling and cardiac hypertrophy. Inhibition of oxidative stress can slow down the formation of cardiac hypertrophy,which plays an important role in the prevention of heart failure. As a classic anti-oxidative stress signaling pathway. Kelch-like ECH-associated protein 1(Keap1)/nuclear factor 2 associated factor 2(Nrf2)/antioxidant response element(ARE) signaling pathway can reduce oxidative stress,protect damaged myocardium,reduce myocardial fibrosis and improve cardiac hypertrophy by activating anti-oxidative stress mechanism in vivo. The purpose of this paper is to summarize the research progress of traditional Chinese medicine(TCM) in improving myocardial hypertrophy by regulating Keap1/Nrf2/ARE signaling pathway,and to provide ideas for improving myocardial hypertrophy by TCM. |
| Key words: traditional Chinese medicine cardiac hypertrophy oxidative stress |
