通心络胶囊结合丁苯酞治疗对颈动脉支架植入术后再狭窄及血流动力学的影响

Effect of Tongxinluo Capsule combined with butylphthalein on restenosis and hemodynamics of carotid artery after stent implantation

关键词:  通心络胶囊  颈动脉支架植入术  再狭窄  血流动力学

Key words:  Tongxinluo Capsule  carotid artery stenting  restenosis  hemodynamics

摘要:

[目的] 探讨通心络胶囊结合丁苯酞治疗对颈动脉支架植入术后再狭窄、血流动力学的影响。[方法] 选取2021年7月—2022年7月河北以岭医院收治的80例颈动脉支架植入术患者，依据随机数字表法分为两组，术后对照组40例采用丁苯酞治疗，观察组40例在此基础上给予通心络胶囊治疗，对比两组预后。[结果] 观察组血压达标率高于对照组（P＜00.05），组间血糖达标率、血脂达标率对比（P＞00.05），但观察组数据略高于对照组。治疗后观察组一氧化氮（NO）高于对照组，内皮素-1（ET-1）低于对照组（P＜0.05）。治疗后观察组C反应蛋白（CRP）低于对照组（P＜00.05），组间同型半胱氨酸（Hcy）对比（P＞00.05）。因复诊意识薄弱、交通、就诊距离远、通讯地址更换等原因，观察组失访2例。随访期间，两组缺血事件、再狭窄发生率对比（P＞0.05），但观察组数据较低。[结论] 通心络胶囊结合丁苯酞用于颈动脉支架植入术后，能修复血管内皮功能、延缓动脉粥样进程、调节炎性因子、促血液循环，降低远期再狭窄及缺血事件。

Abstract:

[Objective] To investigate the effects of Tongxinluo Capsule combined with butylphthalein on restenosis and hemodynamics of carotid artery after stent implantation. [Methods] A total of 80 patients with carotid artery stenting admitted to Yiling Hospital in Hebei Province from July 2021 to July 2022 were selected, divided into two groups. After surgery, 40 patients in the control group were treated with butylphthalein, and 40 patients in the observation group were treated with Tongxinluo Capsule on this basis. The prognosis of the two groups was compared. [Results] The blood pressure meeting rate of the observation group was higher than that of the control group（P<0.05）, and the blood glucose meeting rate and blood lipid meeting rate among the groups were compared（P>0.05）, but the data of the observation group was slightly higher than control group. After treatment, nitric oxide（NO） in observation group was higher than that in control group, and endothelin-1（ET-1） was lower than control group（P<0.05）. C-reactive protein（CRP） in observation group was lower than that in control group（P<0.05）, and homocysteine（Hcy） was compared between groups（P>0.05）. Due to weak awareness of follow-up, transportation, long distance, and change of communication address, 2 cases were lost in the observation group. During the follow-up period, the incidence of ischemic events and restenosis was compared between the two groups（P>0.05）, but the data in the observation group was lower. [Conclusion] Tongxinluo Capsule combined with butylphthalein can repair vascular endothelial function, delay atherosclerosis process, regulate inflammatory factors, promote blood circulation, and reduce long-term restenosis and ischemic events after carotid artery stenting.