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| 基于“浊毒-微生态”理论探析腹泻型肠易激综合征 |
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周金业1,2, 张浩锋1, 王艺灿1, 刘紫薇1, 程祎睿1, 才艳茹3, 姜建明1, 杨倩3,4,5, 李博林3,4
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1.河北中医药大学研究生院, 石家庄 050091;2.易县中医医院, 保定 074200;3.河北省中医院, 石家庄 050011;4.河北省浊毒证重点实验室, 石家庄 050011;5.河北省中西医结合胃肠病研究重点实验室, 石家庄 050011
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| 摘要: |
| 文章从“浊毒-微生态”理论出发，探析腹泻型肠易激综合征，认为“浊毒”可通过影响肠道菌群平衡、介导肠道屏障损伤、干扰胆汁酸的分泌代谢及精神心理调节等方式，导致肠道稳态失衡，参与腹泻型肠易激综合征的发生发展。在“浊毒-微生态”理论指导下治疗腹泻型肠易激综合征，健脾运枢，疏肝调气，以平为期；辨证选用清热化浊、温中化浊、解毒祛瘀等法助肠道微生态复衡，以期为腹泻型肠易激综合征的临床治疗提供新的思路。 |
| 关键词: “浊毒-微生态”理论 腹泻型肠易激综合征 病因病机 治疗 |
| DOI：10.11656/j.issn.1673-9043.2024.12.14 |
| 分类号:R574.4 |
| 基金项目:国家科技部重点研发课题项目（2018YFC1704102）;河北省中央引导地方科技专项项目资助（246Z7708G）;2014年政府资助省级临床医学优秀人才项目（ZF2023160）;河北省“三三三人才工程”资助项目（C20221097）;河北省中医药管理局科研计划项目（2025218，2024010）。 |
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| Analysis of diarrhea type irritable bowel syndrome based on the theory of “turbidity poison-microecology” |
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ZHOU Jinye1,2, ZHANG Haofeng1, WANG Yican1, LIU Ziwei1, CHENG Yirui1, CAI Yanru3, JIANG Jianming1, YANG Qian3,4,5, LI Bolin3,4
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1.Graduate School of Hebei University of Traditional Chinese Medicine, Shijiazhuang 050091, China;2.Yixian Traditional Chinese Medicine Hospital, Baoding 074200, China;3.Hebei Province Hospital of Traditional Chinese Medicine, Shijiazhuang 050011, China;4.Hebei Key Laboratory of Turbidity Toxin Syndrome, Shijiazhuang 050011, China;5.Hebei Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Shijiazhuang 050011, China
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| Abstract: |
| Article from the theory of "turbidity poison-micro ecology",analysis diarrhea type irritable bowel syndrome,think "turbidity poison" can by affecting the intestinal flora balance,mediated intestinal barrier damage,interfere with the secretion of bile acid metabolism and psychological regulation,lead to intestinal homeostasis imbalance,participate in the development of diarrhea type irritable bowel syndrome. Under the guidance of the theory of diarrhea,the spleen should regulate qi,and use fragrance turbidity,heat clearing and turbidity,detoxification and removing stasis to provide new ideas for the clinical treatment of diarrhea IBS. |
| Key words: turbidity poison-microecological theory diarrhea type irritable bowel syndrome etiology and pathogenesis treatment |
