PINK1/Parkin信号通路介导线粒体自噬在中西医防治帕金森病中的研究进展

Research progress on PINK1/Parkin pathway-mediated mitophagy in the prevention and treatment of Parkinson’s disease with integrated Chinese and Western medicine

关键词:  中西医  帕金森病  PTEN诱导的假定激酶1  帕金蛋白  作用机制  研究进展

Key words:  integrated Chinese and Western medicine  Parkinson’s disease  PINK1  Parkin  mechanism of action  research progress

摘要:

帕金森病（PD）是一种临床常见的神经退行性疾病，发病机制复杂，目前临床治疗效果有限，疾病进展难以得到有效控制。线粒体功能障碍是导致神经元损伤的关键因素，而线粒体稳态失衡是引发线粒体功能障碍的重要环节。PD的发生与发展常伴随神经元中的线粒体稳态破坏。线粒体自噬作为调控线粒体稳态的核心机制，对PD的防治具有重要意义。PTEN诱导的假定激酶1（PINK1）/帕金蛋白（Parkin）通路是调控线粒体自噬的经典途径之一。目前，研究发现一些药物和针灸治疗PD可以通过调节PINK1/Parkin信号通路，靶向改善神经元线粒体稳态，从而发挥神经保护作用，特别是中医药调控PINK1/Parkin通路介导的线粒体自噬对PD的干预作用备受关注。文章从PINK1/Parkin通路角度，综述PINK1/Parkin介导的线粒体自噬对PD的影响，并探究中西医通过调控该通路对PD的治疗作用，旨在为中西医防治PD提供新的研究思路。

Abstract:

Parkinson’s disease（PD） is a common neurodegenerative disorder with a complex pathogenesis. Current clinical treatments have limited efficacy，making it difficult to effectively control disease progression. Mitochondrial dysfunction is a key factor leading to neuronal damage，and the imbalance of mitochondrial homeostasis is a crucial link in triggering mitochondrial dysfunction. The occurrence and development of PD are often accompanied by the disruption of mitochondrial homeostasis in neurons. Mitophagy，as a core mechanism regulating mitochondrial homeostasis，is of great significance for the prevention and treatment of PD. The PTEN-induced putative kinase 1（PINK1）/Parkin pathway is one of the classical pathways regulating mitophagy. Currently，studies have found that certain drugs and acupuncture treatments for PD can exert neuroprotective effects by modulating the PINK1/Parkin signaling pathway to target and improve neuronal mitochondrial homeostasis. In particular，the intervention of traditional Chinese medicine in regulating PINK1/Parkin pathway-mediated mitophagy for PD has attracted much attention. The article reviews the impact of PINK1/Parkin-mediated mitophagy on PD from the perspective of the PINK1/Parkin pathway and explores the therapeutic effects of both Chinese and Western medicine on PD by regulating this pathway，aiming to provide new research insights for the prevention and treatment of PD with integrated Chinese and Western medicine.