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| 肠道菌群对高血压病的风险影响及中医药干预理论 |
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郭俊池1,2, 杨培丽1,2, 张明妍3, 赵英强1, 路美娟1
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1.天津中医药大学第二附属医院心血管内科, 天津 300250;2.天津中医药大学研究生院, 天津 301617;3.天津中医药大学中医学院, 天津 301617
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| 摘要: |
| [目的] 该研究旨在基于孟德尔随机化（MR）方法探讨肠道菌群与高血压病之间的因果关系，并进一步分析特定菌群在高血压病风险中的作用。[方法] 该研究采用IVW法、MR-Egger法和加权中位数法等三种孟德尔随机化分析方法，选取两样本数据，评估不同肠道菌群对高血压病风险的影响。研究所用数据来自公开的基因组关联研究（GWAS）数据库，肠道菌群作为暴露因素，高血压病作为结局变量。[结果] MR结果显示，特定肠道菌群如放线菌门、德美克氏菌科、吉欧氏菌科等与高血压病的风险显著正相关，而醋酸杆菌科、独岛菌属等菌群则与降低高血压病风险有关。多种分析方法结果一致，增强了结果的稳健性。[结论] 该研究通过MR分析，证实了特定肠道菌群与高血压病之间的因果关联，为高血压病的预防和干预提供了新的思路。此外，中医药的整体调节作用在恢复肠道菌群平衡和高血压病防治中具有重要潜力，值得进一步研究与应用。 |
| 关键词: 孟德尔随机化 肠道菌群 高血压病 中医药 |
| DOI：10.11656/j.issn.1673-9043.2026.02.04 |
| 分类号:R544.1;R2-03 |
| 基金项目:2024年度国家自然科学基金面上项目（82374619）；2023年度天津市卫健委中医中西医结合项目（2023027）；2021年度天津市教委科研计划自然重点项目（2021ZD028）；2024年度天津中医药大学研究生科研创新项目（YJSKC20240042）。 |
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| Exploring the impact of gut microbiota on hypertension risk and the theory of traditional Chinese medicine intervention |
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GUO Junchi1,2, YANG Peili1,2, ZHANG Mingyan3, ZHAO Yingqiang1, LU Meijuan1
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1.Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Department of Cardiology, Tianjin 300250, China;2.Tianjin University of Traditional Chinese Medicine, Graduate School, Tianjin 301617, China;3.Tianjin University of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| [Objective] This study aims to explore the causal relationship between gut microbiota and hypertension using Mendelian Randomization（MR）methods，and to further analyze the role of specific microbiota in hypertension risk. [Methods] The study employed three Mendelian Randomization analysis methods：Inverse-Variance Weighted （IVW），MR-Egger，and Weighted Median，using two-sample data to evaluate the impact of different gut microbiota on hypertension risk. The data used in this study were obtained from publicly available Genome-Wide Association Study（GWAS）databases，with gut microbiota as the exposure factor and hypertension as the outcome variable. [Results] The MR results indicated that certain gut microbiota，such as Actinobacteria，Desulfovibrionaceae，and Geobacteraceae，were significantly positively associated with an increased risk of hypertension，while microbiota such as Acetobacteraceae and Dokdonella were associated with a reduced risk of hypertension. The consistency of results across multiple analysis methods strengthens the robustness of the findings. [Conclusion] This study confirmed，through MR analysis，a causal relationship between specific gut microbiota and hypertension，providing new insights for hypertension prevention and intervention. Additionally，the overall regulatory effects of Traditional Chinese Medicine（TCM） in restoring gut microbiota balance and hypertension management hold significant potential，warranting further research and application. |
| Key words: Mendelian Randomization gut microbiota hypertension traditional Chinese medicine |
