谷氨酰胺代谢在癌症中的治疗作用及中药干预研究进展

Research progress in therapeutic role of glutamine metabolism in cancer and intervention of traditional Chinese medicine

关键词:  谷氨酰胺  代谢重编程  癌症  中药  研究进展

Key words:  glutamine  metabolic reprogramming  cancer  Chinese medicine  research progress

摘要:

代谢重编程是癌症的最重要特征之一。最新研究表明, 谷氨酰胺代谢参与肿瘤细胞的恶性增殖、侵袭和转移, 同时还促进肿瘤产生新生血管等作用, 是靶向癌症能量代谢的重要策略之一, 并成为抗肿瘤领域的研究热点。近年来中药被发现能通过调控谷氨酰胺代谢参与肿瘤发生发展进程。基于此, 文章对肿瘤细胞中谷氨酰胺代谢的特征及调控机制进行综述, 并探讨中药对谷氨酰胺代谢的干预作用, 为靶向谷氨酰胺代谢治疗癌症带来启发。

Abstract:

Metabolic reprogramming is one of the most important characteristics of cancer. Recent studies have shown that glutamine metabolism is involved in the malignant proliferation, invasion and metastasis of cancer cells, and also promotes the formation of new blood vessels in tumors, which is one of the important strategies to target cancer energy metabolism and has become a research hotspot in the field of anti-tumor. In recent years, it has been found that traditional Chinese medicine can participate in the tumorigenesis and development by regulating glutamine metabolism. Based on this, this paper reviewed the characteristics and regulatory mechanisms of glutamine metabolism in tumor cells, and discussed the intervention effect of traditional Chinese medicine on glutamine metabolism, which provided inspiration for targeting glutamine metabolism in the treatment of cancer.