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| Experimental study on the protective mechanism of traditional Chinese medicine (Xinshen Ⅰ Prescription) against stress ulceration in rats |
| Hits 1800 Download times 1651 Received:April 10, 2007 |
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| DOI
10.11656/j.issn.1673-9043.2007.02.05 |
| Key Words
stress ulceration;Xinshen Ⅰ Prescription;experimental study |
| Author Name | Affiliation | | LU Guang-xiang | 天津中医药研究院 300120 | | WU Cheng | 天津中医药研究院 300120 | | LI Hui-ji | Tianjin Research Institute of TCM, Tianjin 300193, China |
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| Abstract
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| [Objection] To explore the protective mechanism of Xinshen (spirit and body) Ⅰ Prescription against stress ulceration in rats.[Methods] All the rats were randomly divided into three groups:model group,normal group,Xinshen Ⅰ group.The rats of Xinshen Ⅰ Prescription group were administrated with Xinshen Ⅰ Prescription and that of model and normal group with normal saline.The general state,the gastric acid and mucosa change and substance P change of cerebral enteropetide and curative effect of Xinshen Ⅰ Prescription were observed.[Results] The pH value of model group was obviously higher than that of normal group (P<0.05) and the pH value of model group was not obviously different compared with that of Xinshen Ⅰ Prescription group (P>0.05).So Xinshen Ⅰ Prescription didn't enhance the pH value of gastric juice. The mucosa ulcer index of model group was obviously higher than that of normal group (P<0.01) and the mucosa ulcer index of Xinshen Ⅰ Prescription group was obviously lower than that of model group (P<0.05).Xinshen Ⅰ Prescription might obviously decrease the content of substance P in plasma,brain tissue and stomach mucosa (P<0.01).[Conclusion] Xinshen Ⅰ Prescription may obviously protect the stomach mucous membrane,the integrality of cellular construction, and prevent the formation of ulcer.Its mechanism may be related to the excessive high content of substance P in the blood plasma,brain tissue and stomach mucosa. |
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