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| Effect of children kangxian capsule on GABA-Y activity in the brain of rats with epilepsia |
| Hits 1525 Download times 1478 Received:October 10, 2008 |
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| DOI
10.11656/j.issn.1673-9043.2009.01.09 |
| Key Words
children anti-epilapsia capsule;epilepsia;γ-GABA |
| Author Name | Affiliation | | TIAN Shu-xia | Tianjin University of TCM, Tianjin 300193, China | | LI Xin-min | 天津中医药大学第一附属医院 300193 |
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| Abstract
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| [Objective] On the basis of past researches in the traditional Chinese medicine the effect of children anti-epilepsy capsule was observed in pentylenetetrazol (PTZ)-kindled model of rats and the mechanism of anti-epilepsy capsule was investigated at an angle of regulating metabolism of,γ-aminobutiric acid (GABA).[Method] The model of pentylenetetrazol (PTZ)-kindled epilepsy was used in the experiment.The activity of γ-aminobutiric acid-transaminase in homoginized brain tissue of the rats was measured with microultraviolet spectrophotometry.[Results] The body weight of the antiepilepsy capsule group,sodium valproate group and the PTZ model group were significantly different when compared with the control group (P<0.01).The weight of the anti-epilepsy capsule group was significantly diff erent compared with that of the PTZ model group (P<0.01).the activity of,γ-aminobutiric acid-transaminase in the brain of model group was significantly higher than that in normal group (P<0.01).The activity in group treated with Chinese medicine was obviously lower than that in model group (P<0.01).[Conclusion] The mechanism of anti-epilepsy capsule on epilepsy may be related to decreasing the GABA-transaminase activity and the level of Glu in the cortex and hippocampus of the rats and to increasing the level of the GABA in the cortex and hippocampus of the rats. |
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