穿地龙对角叉菜胶所致小鼠足跖肿胀抗炎肿作用的观察

Observation of Anti-inflammation of Chuandilong’s in Carrageenin-induced in Mouse Metatarsus

关键词:  穿地龙  小鼠  炎症  足跖肿胀

Key words:  Chuandilong  mouse  inflammation  metatarsal swelling

摘要:

目的: 探讨穿地龙在关节炎中抗炎作用的效果。方法: 采用角叉菜致小鼠足水肿的急性非感染炎症模型,设立模型组、普威对照组,用不同剂量穿地龙水煎剂于造模前3d给小鼠灌胃,1次/d,千分尺测量造模前及造模后2、4、6、8、24h足跖垫厚度及检测24h血清唾液酸水平。结果: 穿地龙可明显减轻模型8、24h小鼠足肿胀(P<0.05),对小鼠血清唾液酸水平没有影响。结论: 提示穿地龙在这种急性炎症模型中有抗急性炎症作用。

Abstract:

Objective: To study the anti-inflammatory effect of Chuandilong (dioscorea nipponica) on arthritis. Methods: The model of acute non-infectious inflammation was induced by carrageenin. There were 2 groups: model group and control group (given Nimesulide).Chuandilong with different dosage, once a day, was given to all mice 3 days before the models were made. The thickness of metatarsus was measured before and 2, 4, 6, 8, 24 hours after the models were made. And serum salivary sialic acid was tested 24 hours after that.Results: Chuandilong could improve the swelling at 8, 24 hours obviously (P<0.05), and has no effect on serum sialic acid. Conclusion: Chuandilong has an anti-inflammatory effect on this mode.