心舒康对压力负荷增加大鼠心肌蛋白激酶表达的实验研究

Experiment Study of Effect of Xinshukang on Myocardium Protein Kinase Expression in Rats with Increasing Pressure Load

关键词:  心舒康  蛋白激酶  高血压左心室肥厚  压力负荷增加大鼠

Key words:  Xinshukang  protein kinase  left ventricular hypertrophy in hypertension  rats with increasing pressure load

摘要:

[目的] 观察心舒康对压力负荷增加大鼠心肌组织蛋白激酶表达的影响,以探讨其防治高血压左心室肥厚的作用机制。[方法] 肾动脉部分结扎建立压力负荷增加大鼠心肌肥厚模型,观察左心室质量指数及心肌组织蛋白激酶表达的改变。[结果] 模型组左室质量指数(LVMI%)明显高于空白组(P<0.01),心舒康组较模型组明显下降(P<0.01),心舒康组较开博通组明显下降(P<0.01);模型组心肌组织蛋白激酶C(PKC)呈高表达,心舒康组心肌蛋白激酶表达较模型组明显降低(P<0.05),心舒康组较开博通组也有显著下降(P<0.01)。[结论] 心舒康可降低压力负荷增加大鼠心肌组织蛋白激酶的高表达,从而逆转其左心室肥厚。

Abstract:

[Objective] To observe the effect of Xinshukang on myocardium protein kinase expression of rats with increasing pressure load and explore the mechanism of preventing and curing left ventricular hypertrophy in hypertension.[Methods] The myocardial hypertrophy in rats was established with increasing pressure load by ligating partly renal artery and the weight index of left ventricle and the expression of myocardium protein kinase were observed.[Results] The LVMI% of model group was obviously higher than that of normal group(P<0.01). However,the LVMI% of Xinshukang group was obviously lower than that of model group and Captopril group(P<0.01). The myocardium protein kinase expression (PKC) was highly expressed in model group. The PKC of Xinshukang group was more decreased than that of model group(P<0.05) and It was also less than that of Captopril group(P<0.01).[Conclusions] Xinshukang may decrease the high expression of myocardium protein kinase in rats with increasing pressure load and reverse the left ventricular hypertrophy.