抑抗安胎饮对免疫复发性流产患者血清抗体及T淋巴细胞亚群的影响

Effect of Yikang’antai decoction on serum antibody and T cell subgroups in patients with immuno-recurrent abortion

关键词:  抑抗安胎饮  免疫复发性流产  血清抗体  T淋巴细胞亚群

Key words:  Yikang’antai decoction  recurrent spontaneous abortion  serum antibody  T cell subgroups

摘要:

[目的]观察抑抗安胎饮对免疫异常增高型复发性自然流产(RSA)阴虚证患者妊娠前后免疫状态变化、胚胎丢失率情况。[方法]选择血型抗体阳性的患者及抗心磷脂抗体阳性的患者各80例,另外选择血清抗体阳性合并雌二醇(E₂)及孕酮(P)水平低下患者40例,随机分为治疗组和对照组,将血型抗体阳性治疗组和抗心磷脂抗体阳性治疗组的患者均予以抑抗安胎饮,1剂/d,水煎服,3个月为1个疗程。抗心磷脂抗体阳性对照组患者予阿斯匹林口服(50mg,每晚1次);血型抗体阳性对照组患者予50%葡萄糖溶液40mL+维生素C静脉推注,1次/d,每个疗程连用10d,疗程同治疗组。服药期间避孕,第1个疗程结束后,嘱患者停止避孕,再次妊娠后为第2个疗程,用药至12周。[结果]抑抗安胎饮能降低血型抗体和抗心磷脂抗体(ACA)滴定度,提高血清E₂、P水平;使CD⁴⁺值升高,CD⁸⁺值下降,两者比值升高,使白细胞介素-2(IL-2)值下降,白细胞介素-4(IL-4)值升高。[结论]抑抗安胎饮不仅能抑制抗心磷脂抗体、血型抗体的产生,且能抑制其对胚胎的损伤作用,调整机体的免疫机能,改善患者的生殖能力,即在不同环节和机制上发挥不同的作用。

Abstract:

[Objective] To further explore the correlated pathogenic reasons and pathogenesis in patients with recurrent spontaneous abortion (RSA) by using modern immunology and molecular biology technology. The effect of Yikang’antai(inhibiting the antibody and miscarriage preventin) decoction on the immune state change and embryo loss rate before and after pregnancy of patients with yin insufficiency hyper-immunologic abnormality. [Methods] Eighty patients with positive blood group antibody and anticardiolipin antibody(ACA) and forty patients with positive blood group antibody combined with low E₂ and P level were examined. These selected patients were randomly divided into treatment group and control group. The patients of treatment group were treated with Yikang’antai decoction and those of control group were individually treated with aspirin tablet and vitamin C injection. In the first course of treatment the patients would be managed with birth control and stop contraception. The second course of treatment was carried out twelve weeks after pregnancy again. [Results] Yikang’antai decoction may decrease blood group antibody and ACA titer and increase serum E₂, P level. Yikang’antai decoction could decrease IL-4 and increase IL-2 by increasing the ratio of CD⁴⁺ and CD⁸⁺. [Conclusion] Yikang’antai decoction may inhibit not only ACA and blood group antibody but also embryonic injury effect. Yikang’antai decoction may generate comprehensive effect by regulating body immunization function and improving patient’s reproductive activity.