益气养阴活血中药改善2型糖尿病患者胰岛素抵抗的临床研究

Clinical research on effect of YiqiYangyinHuoxue(supplementing Qi, nourishing Yin and activating Blood circulation decoction) in improving insulin resistance in patients with type 2 diabetes

关键词:  益气养阴活血中药  2型糖尿病  胰岛素抵抗

Key words:  traditional Chinese medicine of supplementing qi, nourishing yin and activating blood circulation  type 2 diabetes mellitus  insulin resistance

摘要:

[目的]探讨益气养阴活血中药改善气阴两虚血瘀型2型糖尿病患者胰岛素抵抗的临床疗效。[方法]将110例2型糖尿病伴胰岛素抵抗患者随机分为对照组和治疗组。两组基础治疗均为口服降糖西药并进行饮食控制,治疗组在此基础上加用益气养阴活血中药,3个月为1个疗程。主要观察治疗前后空腹血糖(FBG)、餐后2h时血糖(2hBG)、空腹血胰岛素(Fins)、糖化血红蛋白(HbAlc)、凝血功能等指标的变化,并计算胰岛素抵抗指数(HOMA-IR)。[结果]两组患者治疗3个月后,FBG、2hBG、Fins、HbAlc、HOMA-IR及凝血指标均有不同程度的明显改善,但以治疗组改善更明显。[结论]益气养阴活血中药在防治和改善2型糖尿病患者的胰岛素抵抗及血液高凝状态方面具有一定的疗效。

Abstract:

[Objective] To study the therapeutic effect of integrated use of Chinese and Western medicine(ICWM) on the improvement of insulin resistance(IR) in patients with both deficiencies of vital energy and yin and blood stasis in patients of type 2 diabetes. [Methods] One hundred and twenty cases of IR patients were randomly divided into two groups: control group and treated group with 60 patients in each group. They were treated respectively with Western medicine and diet control, the patients of treated group, in addition to above treatment, were given some Chinese medicine, which could supplement qi(vital energy), nourish yin(body constitution) and activate blood circulation. The observation period was three months. Fasting blood glucose(FBG), 2 hours post meal blood glucose(2hBG), fasting insulin(Fins), glycosylated hemoglobin(HbAlc), blood fat, blood coagulation were observed before and after treatment, then the index of IR were calculated. [Results] The FBG, 2hBG, Fins, HbA1c, HOMA-IR, blood fat and blood coagulation of treatment group was obviously improved when compared with that of control group. [Conclusion] This kind of traditional Chinese medicine has a curative effect in preventing and improving insulin resistance, blood fat disorder and serum hypercoagulabale state in patients with type 2 diabetes.