| 摘要: |
| [目的]研究心身1号片(XS-1)抗实验性大鼠胃溃疡的药理作用及机制。[方法]用浸水-束缚应激法和醋酸烧灼法分别制作胃溃疡模型,观察心身1号片对胃溃疡的保护修复作用和对胃黏膜凋亡相关基因B细胞淋巴瘤/白血病基因-2(BcL-2)和BcL-2相关蛋白(Bax)表达的影响。[结果]XS-1对大鼠水浸应激性胃溃疡的形成有显著预防的作用(P<0.01);对乙酸烧灼性溃疡有显著治疗作用(P<0.01)。两组模型中,XS-1组Bcl-2阳性细胞数目较造模组增多,两者具有明显差异(P<0.01);造模组Bax阳性细胞数目较心身1号片组增多,两者具有明显差异(P<0.01)。[结论]中药XS-1能够促进溃疡大鼠胃黏膜组织Bcl-2的表达,降低Bax的表达,这可能是XS-1抗溃疡的作用机制之一。 |
| 关键词: 胃溃疡 凋亡 B细胞 淋巴瘤因子 X蛋白 心身1号片 |
| DOI：10.11656/j.issn.1672-1519.2008.05.27 |
| 分类号: |
| 基金项目:天津市卫生局中医、中西医结合科研课题专项基金课题(2007023) |
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| Study on protectve and reparing effect of "Xinshenyihao" in mucosa of rats with gastric ulcer |
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BAI Li-jun,JIA Xi-lian,WU Cheng
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1.Tianjin Medical University, Tianjin 300070, China;2.The General Hospital of Tianjin Medical University, Tianjin 300052, China;3.The Affiliated Hospital of Tianjin Academy of TCM, Tianjin 300120, China
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| Abstract: |
| [Objective] To study the pharmacological action and mechanism of "Xinshenyihao" (XS-1) in treating rats with experimental gastric ulcer. [Methods] Gastric ulcer was induced in rats by using soaking and restraining stress and acetic acid damage to study the function of XS-1 in protecting and repairing gastric ulcer, and the effect of XS-1 on the expression of Bcl-2 and Bax in rats with gastric ulcer was also determined. [Results] XS-1 played a significantly role in treating both acetic ulcer and in preventing stress ulcer. In both model groups, Bcl-2 positive cells in the XS-1 treated groups were significantly more than those in the model groups (P<0.01). In contrast,Bax positive cells in the model groups were significantly more than those in the XS-1-treated groups (P<0.01). [Conclusion] The traditional Chinese medicine Xinshenyihao can enhance the expresstion of Bcl-2 and reduce the expresstion of Bax in mucosa of rats with gastric ulcer. This might be one of its mechanisms. |
| Key words: Gastric Ulcer Apoptosis Bcl-2 Bax Xinshenyihao |
