温肾化石汤防治含钙尿石复发的临床研究

Clinical study on preventing and treating calcium-containing urinary stone with Wenshen Huashi Decoction

关键词:  温肾化石汤  含钙尿石  临床研究

Key words:  Wenshen Huashi Decoction  calsium-containing urinary stone  clinical research

摘要:

[目的]通过观察温肾化石汤对含钙尿石形成相关指标的影响,探讨该方防治含钙尿石复发的机制,为防治含钙尿石复发开创新思路,提供新方法。[方法]选择符合条件的尿石症患者40例,随机分为两组,治疗组20例,服用"温肾化石汤",1剂/d,水煎服,分早晚两次服用。对照组20例,服用双氢克尿噻50mg/次,2次/d。两组均以14d为1个疗程,观察治疗前后各相关指标的变化。[结论]"温肾化石汤"可以显著降低新鲜晨尿pH值、尿中钙、磷、草酸等尿石形成促进物的浓度;增加24h总尿量、尿中镁、柠檬酸、GAGs含量尿石形成促进物的浓度(P<0.05)。[结论]温肾化石汤既可降低尿石形成促进物的浓度,又能提高尿石形成抑制物的浓度。这可能是本方防治含钙尿石形成与复发的重要作用机制之一。

Abstract:

[Objective] To observe the effect of Wenshen Huashi (warming kidney and dissipating dampness) Decoction on the pH value of fresh morning urine, the total urine volume of 24 hours, calcium (Ca), magnesium (Mg), phosphoruse (P), citric acid, gly-cosaminoglycans (GAGs), and to explore the mechanism of it in treating and preventing urinary stone.[Methods] Forty patients with urolithiasis were divided into treat group and control group at random, treating with warming kidney and dissipating dampness decoction and dihydrochlorothiazide (DCT) respectively for 14 days. Then the total urine volume of 24 hours, pH value of fresh morning urine, the content of promoting substances, including Ca, P oxalic acid, the content of restraining substance such as Mg, citric acid and GAGs were observed before and after treatment. The data were statistically analyzed with T test. [Result] Wenshen Huashi Decoction could reduce the pH value of the fresh morning urine, the density of promoting substances including Ca, P oxalic acid, increase the urine volume of 24 hours, the density of restrain substances such as Mg, citric acid and GAGs in the urine (P<0.05). [Conclusion] Wenshen Huashi Decoction can reduce the density of promoting substances and increase the density of restraining substances in the urine. It may be one of the important mechanisms of Wenshen Huashi Decoction in preventing and treating calsium-containing urinary stone.