| 摘要: |
| [目的]利用正交实验优选齐墩果酸分散片的最佳处方。[方法]以齐墩果酸溶出度为指标,采用正交设计实验,对处方配比进行筛选。[结果]优化处方为:交联聚维酮(PVPP):羧甲基淀粉钠(CMS-NA):乳糖:微晶纤维素(MCC):微粉硅胶:PEG-6000=4:3:30:15:1:1。优化后齐墩果酸分散片溶出度为89%,较普通片有明显的提高。[结论]分散片处方合理、工艺可行,符合分散片的质量要求。 |
| 关键词: 分散片 正交 溶出度 齐墩果酸 高效液相色谱 |
| DOI：10.11656/j.issn.1672-1519.2011.02.28 |
| 分类号: |
| 基金项目:国家科技支撑计划项目(2007BAI41B06) |
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| Optimization of prescriptions of dispersible tablets of oleanolic acid |
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WANG Long1, MA Li2, HAN Feng2
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1.Tianjin University of TCM, Tianjin 300193, China;2.Tianjin Institude of Pharmaceutical Research, Tianjin 300193, China
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| Abstract: |
| [Objective] To screen the optimum prescription for oleanolic acid of dispersible tablets by orthogonal design.[Methods] Taking the dissolution rate as an index and using the orthogonal experimental design the prescription match was ultimately determined.[Results] The optimized prescription is: PVPP : CMS-NA : lactose : MCC : silicon gel : PEG-6000=4 : 3 : 30 : 15 : 1 : 1.After optimization the dissolution rate of the dispersible tablets is 89%,showing a significant increasing.[Conclusion] The optimized prescription is reasonable,the technology is feasible.That is tally with the quality requirements of dispersible tablets. |
| Key words: dispersible tablets orthogonal design dissolution rate oleanolic acid HPLC |
