| 摘要: |
| [目的]观察单药及添加柴贝止痫汤对难治性癫痫(IE)的临床效果与安全性。[方法]采用开放性自身对照试验的方法,对确诊的10例IE患者采用柴贝止痫汤单药治疗、21例IE患者采用添加柴贝止痫汤治疗,经12周治疗后进行评价,观察周期为2011年1—10月。按常规计算有效率。并进行临床观察和实验室检查。[结果]按例数分析,全部31例IE患者,同治疗前比较总有效率为45.16%,其中单药治疗组总有效率为50%,添加治疗组总有效率为42.86%。按发作类型分析(46例次),单药治疗组及添加治疗组IE发作总有效率分别为58.33%和41.18%,对各型癫痫发作的总有效率:单纯部分性发作分别为50%和30%,复杂部分性发作分别为40%和50%,部分发作继发全面性发作分别为75%和50%,全面性发作分别为100%和25%。各型癫痫发作的疗效差异无统计学意义。不良反应为轻至中度,耐受性良好。[结论]柴贝止痫汤治疗难治性癫痫是安全有效的方法之一。 |
| 关键词: 柴贝止痫汤 难治性癫痫 疗效 |
| DOI：10.11656/j.issn.1672-1519.2012.03.05 |
| 分类号: |
| 基金项目:北京中医药大学自主选题项目(2009JYB22-JS092) |
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| Clinical observation of single using Chaibei Zhixian decoction and combined medication on intractable epilepsy |
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ZHENG Xiang-chun, LI Shu-fang, LIU Jin-min
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Emergency Department, Dongfang Hospital Affiliated of Beijing University of TCM, Beijing 100078, China
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| Abstract: |
| [Objective] To study clinical curative effect and safety of single using Chaibei Zhixian decoction and combined medication on intractable epilepsy.[Methods] Using method of the open self control test,the 10 diagnosed cases of IE patients were treated with single using ChaiBei Zhixian decoction,and the 21 patients with were teated by combined medication with ChaiBei Zhixian decoction,after 12 weeks of treatment to evaluate,observation period from January 2011 to October 2011 in order to calculate effective rate,and carry on clinical observation and laboratory examination.[Results] Analysis according to case number,all 31 cases of IE patients compared with before treatment,the total effective rate was 45.16%.The total effective rate of the single using Chaibei Zhixian decoction group was 50%.The total effective rate of combined medication group was 42.86%.Analysis according to seizure types(46 cases),the total effective rate of the single treatment group and combined medication treatment group were 58.33% and 41.18%;the total effective rate of seizure types:the effective rate of topiramate in simple partial seizure were 50% and 30% respectively,complex partial seizure were 40% and 50% respectively;secondary generalized seizure were 75%and 50%respectively,and generalized seizure were 100% and 25% respectively.The curative effect different of various types of epileptic seizures had no significance.Adverse reactions was mild to moderate,well tolerated.[Conclusion] Chaibei Zhixian decoction in treating refractory epilepsy is a safe and effective method. |
| Key words: Chaibei Zhixian decoction intractable epilepsy curative effect |
