痛风宁防治急性痛风性关节炎的实验研究

Experiment study of Tongfengning in preventing and curing acute gouty arthritis

关键词:  急性痛风性关节炎  痛风宁  尿酸  实验研究

Key words:  acute gouty arthritis  Tongfengning  uric acid  experimental study

摘要:

[目的] 探讨痛风宁防治大鼠急性痛风性关节炎的作用机制.[方法] 将70只大鼠随机分为7组,分别为空白组、模型组、中药对照组、西药对照组、痛风宁高、中、低剂量组,每组10只,采用尿酸钠和氧嗪酸钾诱导大鼠急性痛风性关节炎模型,测定大鼠关节肿胀度和大鼠血清尿酸水平.[结果] 痛风宁具有抑制大鼠足肿胀的作用,并能降低大鼠血清尿酸水平.[结论] 痛风宁对大鼠急性痛风性关节炎有一定的防治作用,其中痛风宁高、中剂量组作用明显.

Abstract:

[Objective] To explore the mechanism of the preventing and curing effect of Tongfengning on acute gouty arthritis in rats. [Methods] The 70 rats were randomly divided into seven groups: the blank group, the model group, traditional Chinese medicine control group, Western medicine control group, Tongfengning high, medium and low doses groups, with 10 rats in each group. The uric acid sodium and oxygen polybenzoxazines potassium were used to induce acute gouty arthritis in rats. The joint swelling degree and serum uric acid levels in rats were determined. [Results] Tongfengning could inhibit foot swelling, reduce serum uric acid levels. [Conclusion] Tongfengning has certain preventive and therapeutic effect on acute gouty arthritis in rats. The effect of Tongfengning high dose and medium dose group is more obvious.