| 摘要: |
| [目的] 考察骨碎补外用对环磷酰胺致C57BL/6小鼠斑秃模型的影响.[方法] 采用环磷酰胺腹腔注射建立C57BL/6小鼠斑秃模型,观察骨碎补外用对小鼠毛囊组织学变化和血清细胞间黏附蛋白(ICAM-1)、内皮细胞-白细胞黏附分子-1(ELAM-1)水平的影响.[结果] 骨碎补外用能使实验性斑秃模型小鼠血清ICAM-1和ELAM-1水平降低,毛囊数增多(P < 0.05或P < 0.01).[结论] 骨碎补外用能够抑制毛囊进入退行期,对斑秃模型小鼠具有治疗作用. |
| 关键词: 骨碎补 外用 环磷酰胺 斑秃 |
| DOI：10.11656/j.issn.1672-1519.2012.04.22 |
| 分类号: |
| 基金项目:国家科技支撑计划项目(2008BA153B09). |
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| Experimental effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in mice |
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HUANG Yun-ying, ZHANG De-qin, SHEN Li, WANG Xue-ni, DU Juan, WANG Yuan-yuan
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Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM, Tianjin 300193,China
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| Abstract: |
| [Objective] To investigate the effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in C57BL/6 mice. [Methods] Severe alopecia was induced by cyclophosphamide in these mice. The hair growth and histological changes were observed in the back skin of them. The levels of ICAM-1 and ELAM-1 in the serum were determined by ELISA. [Results] The levels of ICAM-1 and ELAM-1 in herbal group were lower than that in the control group. The nutrition of hair follicles was also improved. [Conclusions] The extract from Drynaria fortunei has a promoting effect on the hair growth by its external application. |
| Key words: Drynaria fortunei external application cyclophosphamide alopecia areata |
