| 摘要: |
| [目的] 探讨鲜生地（冻干粉）对肝损伤模型大鼠肠生物屏障的影响。[方法]采用Pringle’s maneuver法制作大鼠肝缺血再灌注损伤模型。将64只实验大鼠随机分为假手术组、模型组、鲜生地（冻干粉）组及乳果糖组。观察大鼠粪便球杆菌比例、菌落培养，测定血清内毒素水平。[结果] 鲜生地组、乳果糖组粪便中益生菌增加，大肠杆菌减少，血清内毒素水平降低。[结论] 鲜生地能够调节肠道菌群，降低血内毒素水平，可能通过改善肠生物屏障，使肝细胞得到恢复。 |
| 关键词: 鲜生地 肝损伤 生物屏障 |
| DOI：10.11656/j.issn.1672-1519.2014.03.13 |
| 分类号: |
| 基金项目:天津市卫生局科技基金项目（2010kz12）. |
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| Effect of fresh rehmannia (freeze-dried) on intestinal biological barrier in rats with liver injury |
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LI Chen-long1, JIA Jian-wei2, LI Qiu-wei2
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Department of Integrated Chinese and Western Medicine (Division I), The Second People's Hospital of Tianjin, Tianjin 300192, China
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| Abstract: |
| [Objective] To explore the effect of fresh rehmannia (freeze-dried) on intestinal biological barrier in liver damaged rats. [Methods] According to the method of Pringle's maneuver, hepatic ischemia reperfusion was induced in rats. The 64 rats were randomly divided into sham operation group, model group, fresh rehmannia (freeze-dried ) group and the lactulose group. We observed the proportion ratio of coccobacillus in rats' feces, cultured the bacterial colony and measured the level of endotoxin. [Results] In fresh rehmannia group and lactulose group the probiotics was increased, escherichia coli was decreased and the level of endotoxin was decreased. [Conclusion] Fresh rehmannia can regulate the intestinal flora, and reduce blood endotoxin level. It may improve the intestinal biological barrier and recover the liver cells. |
| Key words: fresh rehmannia liver injury biological barrier |
