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| 黄芩素PLGA纳米粒的制备及制剂学性质研究 |
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李楠1,2, 范丽丽1,2, 刘志东1,2, 王爱潮1,2, 郭丽丽1,2, 周沫1,2
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1.天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193;2.天津中医药大学, 现代中药发现与制剂教育部工程研究中心, 天津 300193
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| 摘要: |
| [目的] 优化影响黄芩素聚乳酸/羟基乙酸共聚物（PLGA）纳米粒成型工艺参数，并评价优化工艺后所制纳米粒的制剂学性质。[方法] 采用乳化-溶剂挥发法制备黄芩素PLGA纳米粒，以粒径、包封率为评价指标，单因素实验考察了聚乙烯醇（PVA）浓度、PLGA型号、PLGA分子量、PLGA浓度、水相与有机相体积比、丙酮与无水乙醇体积比、药物与PLGA的比例共7个参数对纳米粒成型工艺的作用规律。[结果] 优化处方工艺制备的纳米粒包封率为（95.03±1.33）%、平均粒径为（126.80±4.50） nm、Zeta电位（-21.30±0.23） mV.[结论] 乳化-溶剂挥发法制备的黄芩素PLGA纳米粒圆整，粒径均一。 |
| 关键词: 黄芩素 乳酸/羟基乙酸共聚物 纳米粒 乳化-溶剂挥发法 |
| DOI：10.11656/j.issn.1672-1519.2014.03.15 |
| 分类号: |
| 基金项目:国家科技重大专项“重大新药创制”项目（2012 ZX09304007）；教育部新世纪优秀人才支持计划（NCET-12-1068A）；天津市自然科学基金项目（12JCYBJC18700）. |
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| Preparation and character in pharmacy of Scutellarein loaded PLGA nanoparticles |
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LI Nan1,2, FAN Li-li1,2, LIU Zhi-dong1,2, WANG Ai-chao1,2, GUO Li-li1,2, ZHOU Mo1,2
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1.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To optimize the processing parameters of Scutellarein loaded PLGA nanoparticles(PLGANP) and study the character in pharmacy of the optimal Scutellarein-PLGANP. [Methods] Seven processing parameters were assessed systematically to enhance the Scutellarein incorporation into PLGA nanoparticles and to minimize the particle size,including PVA concentration in the aqueous phase, PLGA models, PLGA molecular mass, PLGA concentration in the organic phase, aqueous phase/organic phase volume ratio, acetone/ethanol volume ratio, Scutellarein/ PLGA mass ratio. [Results] The Scutellarein-PLGANP produced by the optimal formulation were submicron size of (126.80±4.50) nm and the zeta potential was (-21.30±0.23) mV,with the entrapment efficiency of (95.03±1.33)%. [Conclusion] Scutellarein drug loaded PLGANP can be prepared by O/W emulsion solvent evaporation. |
| Key words: Scutellarein PLGA nanoparticle emulsion solvent evaporation |
