| 摘要: |
| [目的] 优化光甘草定(GLA)羟丙基-β-环糊精包合物(HP-β-CD)的制备工艺,并考察其对体外透皮吸收的影响。[方法] 采用正交实验,考察物料比、包合温度、包合时间对GLA包合率的影响。包合率为指标筛选最佳制备工艺。用Franz扩散池进行透皮吸收实验,研究HP-β-CD对GLA透皮吸收的影响。[结果] HP-β-CD包合GLA的优化工艺是质量倍数为15倍的HP-β-CD,40℃下包合1.5 h。光甘草定HP-β-CD包合物累积透过量高于光甘草定单体组。[结论] HP-β-CD能促进光甘草定的经皮渗透。 |
| 关键词: 光甘草定 羟丙-β-环糊精 透皮吸收 |
| DOI：10.11656/j.issn.1672-1519.2015.10.11 |
| 分类号: |
| 基金项目:西青区科技型中小企业发展专项资金项目(XQKH2013-011);天津中医药大学第四届大学生科技创新基金项目(CXJJ2013ALL)。 |
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| Study on preparation of glabridin hydroxypropyl -β -cyclodextrin inclusion compound and its effect of transdermal absoption |
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YE Liu-qing, WANG Yan, HAN Wan-ying, ZHOU Xiao-xia, MA Zong-wu, GUI Guang-zhi
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School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To optimize the preparation technology of glabridin hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion compound and investigate its effect of transdermal absoption. [Methods] With inclusion efficiency as the indice, the optimum preparation condition was studied by orthogonal test. Franz vertical diffusion cell was adopted to investigate transdermal performance of glabridin HP-β-CD. [Results] The optimal inclusion conditions were as follows: the ratio of glabridin to HP-β-CD was 1∶15 (m/m), inclusion temperature was 40 ℃, inclusion time was 1.5 h. The cumulative permeation of glabridin HP-β-CD was higher than glabridin group. [Conclusion] HP-β-CD have significant effect on transdermal of glabridin. |
| Key words: glabridin HP-β-CD transdermal absoption |
