肾炎益气汤治疗慢性肾小球肾炎临床观察

Clinical observation of the treatment of chronic glomerulonephritis with Nephritis Yiqi decoction

关键词:  慢性肾小球肾炎  中药治疗  肾炎益气汤

Key words:  chronic glomerulonephritis  treatment of traditional Chinese medicine  Nephritis Yiqi decoction

摘要:

[目的] 观察肾炎益气汤治疗慢性肾小球肾炎患者的临床疗效,探讨中医药治疗慢性肾炎的优势和可行性。[方法] 选取本院门诊确诊为慢性肾小球肾炎60例患者,随机分为治疗组30例和对照组30例。两组患者均给予西医常规治疗(利尿、控制血压、应用泼尼松片、控制水盐电解质、酸碱平衡及控制感染等);治疗组患者在常规治疗基础上给予肾炎益气汤随证加减治疗。治疗组和对照组均予治疗3个月,观察临床疗效及相关实验室检查指标的改善情况(治疗前后尿红细胞、24 h尿蛋白定量、血肌酐)。[结果] 经过治疗,治疗组完全缓解5例,缓解7例,有效15例,无效3例,总有效率为90.0%。对照组完全缓解2例,缓解5例,有效6例,无效17例,总有效率为43.3%。两组比较差异有统计学意义(P<0.05)。两组治疗后尿红细胞、24 h尿蛋白定量、血肌酐均较治疗前有显著下降,差异有统计学意义(P<0.05)。治疗组尿素氮与治疗前相比有明显降低,差异有统计学意义(P<0.01)。[结论] 肾炎益气汤治疗慢性肾小球肾炎患者具有较好的临床疗效,能够延缓慢性肾小球肾炎的进程。

Abstract:

[Objective] To observe the clinical curative effect of the treatment of chronic glomerulonephritis patients with Nephritis Yiqi decoction, and to explore the advantages and feasibility of traditional Chinese medicine(TCM) in treating chronic nephritis. [Methods] In this study, 60 cases of chronic glomerulonephritis who were selected from the hospital outpatient service, were randomly divided into treatment group and control group, 30 cases in treatment group and 30 cases in the control group. Two groups of patients were treated with Western medicine routine general treatment(diuretic, blood pressure control, application of prednisone tablet, control water, electrolyte, acid-base balance, and controlling infection, etc.). On the basis of routine therapy, treatment group patients were given Nephritis Yiqi decoction in the add and subtract treatment. The treatment group and the control group were treated for 3 months, to observe the improvement of clinical curative effect and the related laboratory indexes(24 h urinary protein decreased, urine occult blood in urine, serum creatinine). [Results] After treatment, the treatment group was completely relieved in five cases. Seven cases were relieved. Fifteen cases were effective. Three cases were ineffective, and the total effective rate was 90.0%. In the control group, two cases were completely relieved. Five cases were relieved. Six cases were effective. Nineteen cases were ineffective. The total effective rate was 43.3%. The difference between two groups was statistically significant(P<0.05). The urinary RBC, 24 h urine protein quantitative and the serum creatinine between two groups have dropped significantly after treatment, the difference was statistically significant(P<0.05). The urea nitrogen treatment group have significantly lower compared with before treatment, and the difference was statistically significant(P<0.01). [Conclusion] The treatment of chronic glomerulonephritis with Nephritis Yiqi decoction has good clinical effect, and can delay the process of chronic glomerulonephritis.