| 摘要: |
| [目的]观察张曾譻主任验方“心脑血脉宁”治疗甲状腺功能减退症的干预效果。[方法]纳入符合标准的患者，将其分为心脑血脉宁低剂量组、心脑血脉宁高剂量组、单纯甲状腺素片对照组。每组40例，分别施以相应的药物干预，用统计方法分析在治疗 24、48周后患者的临床疗效、证候积分，及影响甲状腺功能减退症的主要指标：血清促甲状腺激素（TSH）、血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）的变化。[结果]1）中药心脑血脉宁高、低剂量两组在治疗24、48周后均能明显改善患者临床疗效、证候积分，能明显降低TSH，升高FT3、FT4数值，差异有统计学意义。2）中药心脑血脉宁高、低剂量两组在改善临床疗效、证候积分方面均优于单纯甲状腺素片对照组。3）心脑血脉宁高剂量组总体疗效优于心脑血脉宁低剂量组。4）治疗48周总体疗效优于24周。[结论]张曾譻主任验方“心脑血脉宁”治疗甲状腺功能减退疗效肯定。在证候改善、临床疗效方面优于西药，且随着服药时间延长及剂量加倍疗效更佳。 |
| 关键词: 心脑血脉宁 甲状腺功能减退 临床疗效 |
| DOI：10.11656/j.issn.1672-1519.2017.06.05 |
| 分类号:R581.2 |
| 基金项目:天津市中医药管理局中医、中西医结合科研专项课题（13013）. |
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| Clinical observation of “Xinnao Xuemai Ning” in the treatment of hypothyroidism |
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REN Yong-li1, REN Ming1, MU Jiao2, ZHANG Zeng-ying3
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1.Department of Diabetes, Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300130, China;2.Department of Acupuncture, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;3.Department of Expert, Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300130, China
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| Abstract: |
| [Objective] To observe the intervention effect of the “Xinnao Xuemai Ning”, ZHANG Zeng-ying's prescription in the treatment of hypothyroidism. [Methods] The patients who meet the requirements were divided into 3 groups: the “Xinnao Xuemai Ning” low dose group, high dose group and the thyroid hormone tablet control group. Forty individuals were in each group. Each group of patients were treated with drugs, to investigate the effects of different doses of “Xinnao Xuemai Ning” after 24 weeks, 48 weeks on the patient's curative effect, symptom score, TSH, FT3, FT4 valued by using the statistical analysis method. [Results] 1)After 24 and 48 weeks treatment, “Xinnao Xuemai Ning” in high and low dose groups can significantly improve the clinical efficacy, integral syndrome, can significantly decrease TSH and increase FT3, FT4 value with statistical significance. 2) “Xinnao Xuemai Ning” high and low dose groups in improving the clinical efficacy, symptom scores were better than the control group. 3) The overall effect of the high dose group was better than that of the low dose group. 4) The curative effect of “Xinnao Xuemai Ning” after 48 weeks was better than after 24 weeks. [Conclusion] Professor ZHANG Zeng-ying's prescription “Xinnao Xuemai Ning” can surely improve the curative effect for treating hypothyroidism. It is better than western medicine in the improvement of syndrome and clinical curative effect and with the longer time and dose more effective. No adverse effect on liver and renal function, medication safety. |
| Key words: Xinnao Xuemai Ning hypothyroidism clinical effect |
