中医药治疗慢性胆囊炎方剂用药规律分析

Analysis on composition and medication regularities of prescriptions of traditional Chinese medicine in treating chronic cholecystitis

关键词:  慢性胆囊炎  中医传承辅助平台  组方规律  数据挖掘

Key words:  chronic cholecystitis  traditional Chinese medicine inheritance support system  prescription rule  data mining

摘要:

[目的]基于中医传承辅助平台软件，分析和总结中医药治疗慢性胆囊炎的用药规律，为进一步挖掘中医药治疗慢性胆囊炎及新药研发提供参考。[方法]收集中国知网（CNKI）中治疗慢性胆囊炎的文献并建立方剂数据库，运用中医传承辅助平台软件对方剂数据库进行四气、五味、归经分布、频次统计、组方规律、新方分析，挖掘其中的用药规律。[结果]筛选治疗慢性胆囊炎的方剂165个，确定了处方中药物出现的频次，常用药对组合，演化得到新处方11个。[结论]中国知网中收录治疗慢性胆囊炎的中药药性以寒、温为主，药味以苦、辛为主，方剂以疏肝利胆、理气解郁、清热利湿、利胆通腑、温寒通阳、活血止痛为主，体现了慢性胆囊炎的临床治疗原则。总结了现代临床治疗慢性胆囊炎的用药规律，有利于指导临床实践，并为临床新药的开发和利用奠定一定的基础。

Abstract:

[Objective] To analyze and summarize the rule of traditional Chinese medicine treatment of chronic cholecystitis based on traditional Chinese medicine inheritance support system, so as to provide reference for further excavation of traditional Chinese medicine in the treatment of chronic cholecystitis and new drug development. [Methods] The literatures on the treatment of chronic cholecystitis in CNKI were collected and the prescription database was established. The software integration data mining method was used to distribute prescriptions according to “four odors”, “five flavors” and “meridians” in the database and achieve frequency statistics, prescription regularity and new prescription analysis. [Results] The 165 prescriptions of chronic cholecystitis were screened, and the frequency of prescription herbs was determined. 11 new prescriptions were obtained. [Conclusion] CNKI contains chronic cholecystitis, cold medicine and warmmedicine, the main flavor is bitterness and symplectic. The prescription is soothing liver and relieving bladder, “regulating qi and antipyresis”, clearing heat removing dampness, “cholaneresis and clear fu”, “warming cold and activating yang”, blood-based analgesic, reflecting the principle of clinical treatment of chronic cholecystitis. This study summarizes the modern clinical treatment of chronic cholecystitis drug rule, is conducive to guiding clinical practice, and clinical drug development and utilization of laid a certain foundation.