参芪山腊梅叶汤对慢性肾功能衰竭患者微炎症因子的影响

Efficacy of Shenqi Shanla Meiye decoction for serum levels of micro inflammatory factor of patients with chronic renal failure

关键词:  参芪山腊梅叶汤  慢性肾功能衰竭  微炎症因子

Key words:  Shenqi Shanla Meiye decoction  chronic renal failure  micro inflammatory factor

摘要:

[目的]观察参芪山腊梅叶汤治疗慢性肾功能衰竭的临床疗效及微炎症因子的影响。[方法]将80例慢性肾功能衰竭患者随机分为观察组40例与对照组40例，对照组给予西医常规治疗。观察组在对照组基础上给予参芪山腊梅叶汤治疗，每日1剂。两组均以3个月为1个疗程。治疗2个疗程后观察两组临床疗效，比较治疗前后中医证候积分、肌酐（Scr）、尿素氮（BUN）、肌酐清除率（CCr）、血清白蛋白（ALB）及超敏C反应蛋白（hs-CRP）、白细胞介素6（IL-6）、肿瘤坏死因子-α（TNF-α）的变化。[结果]观察组总有效率为82.50%，对照组总有效率为57.50%，两组比较差异有统计学意义（P<0.05）.治疗后两组Scr、BUN、IL-6、hs-CRP、TNF-α、中医证候积分均下降（P<0.05或P<0.01），观察组明显低于对照组（P<0.05）.治疗后两组CCr、ALB上升（P<0.05或P<0.01），观察组明显高于对照组（P<0.05）.[结论]参芪山腊梅叶汤有效改善慢性肾功能衰竭的临床症状、肾功能和营养状况。降低hs-CRP、IL-6和TNF-α是其可能作用机制。

Abstract:

[Objective] To evaluate the efficacy of Shenqi Shanla Meiye decoction for patients with chronic renal failure and its effects on serum levels of micro inflammatory factor. [Methods] The 80 patients with chronic renal failure were randomly divided into the observation group and control group, with 40 in each. The control group was treated with routine western medicine. The observation group was added with Shenqi Shanla Meiye decoction one does daily. Both groups were treated for 2 consecutive courses, one treatment course lasted for 3 months. The efficacy was observed and the scores of traditional Chinese medicine(TCM) symptoms, blood urea nitrogen (BUN), serum creatinine (Scr), creatinine clearance rate (CCr), albumin (ALB) and the C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) were detected before and after treatment. [Results] The total effective rate of the observation group and control group was 82.50% and 57.50% respectively, with a significant difference between groups (P<0.05). The scores of TCM symptoms,BUN, Scr, hs-CRP, IL-6, TNF-α in both groups were significantly decreased after treatment (P<0.05 or P<0.01), especially in the observation group (P<0.05). The CCr, ALB in both groups ware significantly improved after treatment (P<0.05 or P<0.01), especially in the observation group (P<0.05). [Conclusion] Shenqi Shanla Meiye decoction can effective relieve the symptoms of chronic renal failure,nutritional status and renal function. Decreasing hs-CRP,IL-6 and TNF-α may be one of its mechanisms.