| 摘要: |
| [目的] 研究吴茱萸对大鼠应激性胃溃疡的作用及其可能的机制。[方法] 实验分为空白对照组、水浸-束缚应激性（WRS）胃溃疡模型组及模型加吴茱萸生药0.45 g/kg体质量组、0.9 g/kg体质量组和1.8 g/kg体质量组，计算各组大鼠胃溃疡指数；采用高效液相色谱-电化学法（HPLC-ECD）检测大鼠血清肾上腺素（E）水平。[结果] 吴茱萸0.45 g/kg组能显著降低溃疡指数（P<0.05）抑制溃疡形成。与模型组相比吴茱萸给药组均能显著抑制血清中E含量（P<0.05）。[结论] 吴茱萸具有抗大鼠应激性胃溃疡的作用，其作用机制可能与调节血清中E含量有关。 |
| 关键词: 吴茱萸 胃溃疡 肾上腺素 |
| DOI：10.11656/j.issn.1672-1519.2017.10.15 |
| 分类号:R285 |
| 基金项目:国家自然科学基金项目（81303247） |
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| Evodia rutaecarpa protects against the irritability gastric ulcer in rats |
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GAO Yun-hang1, NIU Zi-chang2, MAO Hao-ping1
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To investigate the effect of Evodia rutaecarpa in irritability gastric ulcer of rats and its possible mechanism.[Methods] Wistar rats were randomly divided into normal control group, water-immersion restraint stress induced gastric ulcer model group, model and Evodia rutaecarpa 0.45 g/kg group, Evodia rutaecarpa 0.9 g/kg group, and Evodia rutaecarpa 1.8 g/kg group, calculate the gastric ulcer index of rats in each group. The level of serum epinephrine in rats was detected by high performance liquid chromatography with electrochemical method.[Results] Evodia rutaecarpa 0.45 g/kg group could significant reduce ulcer index (P<0.05) and inhibit ulcer formation. Compared with model group, every Evodia rutaecarpa group could definitely inhibit E content in serum.[Conclusion] Evodia rutaecarpa had the effect on inhibition of the irritability gastric ulcer, and its mechanism can be related to regulate content in serum. |
| Key words: Evodia rutaecarpa irritability gastric ulcer epinephrine |
