几种辅料对葛根素液晶纳米粒粒径、电位、包封率的影响

Effect of several materials on the particle size, Zeta potential and encapsulation efficiency of Pue-LCN

关键词:  液晶纳米粒  包封率  粒径  Zeta电位  稳定性

Key words:  liquid crystalline nanoparticle  encapsulation efficiency  particle size  Zeta potential  stability

摘要:

[目的] 为探讨几种辅料（油酸、油酸钠、十八胺、维生素E醋酸酯、吐温80）对葛根素液晶纳米粒粒径、电位、包封率的影响并择最优辅料提高液晶纳米粒的稳定性。[方法] 采用薄膜-分散法制备葛根素液晶纳米粒，以粒径、Zeta电位、pH、包封率为指标筛选最适宜的稳定剂，并考察其对制剂稳定性的影响。[结果] 维生素E醋酸酯最适合作为液晶纳米粒的稳定剂，得到制剂的粒径半径为（94.62±3.18）nm，电位为（-37.47±1.550）mV，体系pH是8.70，包封率可达到92.14%±0.3827%，并且可使周内包封率保持90%以上。[结论] 维生素E醋酸酯可显著提高液晶纳米粒的稳定性，使纳米粒分散良好，粒径均匀。

Abstract:

[Objective] To identify the effect of several materials (oleic acid,sodium oleate,octadecylamine, vitamin E acetate, tween 80) on the particle size, Zeta potential and encapsulation efficiency of puerarin liquid crystalline nanoparticles (Pue-LCN) and select the most proper material to improve the stability of Pue-LCN.[Methods] Pue-LCN was investigated by thin film-dispersion method. The particle size, zeta potential, pH and encapsulation efficiency were used as indexes to select the most suitable stabilizer, and identify the effect the stabilizer on the stability of Pue-LCN.[Results] Vitamin E acetate is the most suitable stabilizer of liquid crystalline nanoparticles, the particle size radius of the preparation was (94.62±3.18) nm, and the potential was (-37.47±1.550) mV. The system pH was 8.70. The encapsulation efficiency reached 92.14%±0.3827%, and week encapsulation rate could be maintained more than 90%.[Conclusion] Vitamin E acetate can significantly improve the stability of liquid crystal nanoparticles. The preparation has good dispersion of nanoparticles and particle size uniformity.