杏苏止咳颗粒成型工艺研究

Preparation technology for Xingsu Zhike granule

关键词:  杏苏止咳颗粒  成型工艺  正交实验设计  D-最优混料设计

Key words:  Xingsu Zhike granule  molding process  orthogonal experiment design  D-the optimum mixture design

摘要:

[目的] 研究杏苏止咳颗粒的最优处方及制备工艺，并对最佳成型颗粒的物理特性进行考察。[方法] 以制粒情况、粉体学参数、吸湿率、成型率及溶化性为主要考察指标，对成型辅料的种类进行单因素考察；以颗粒的吸湿率为指标，采用D-最优混料设计对成型辅料的最优配比进行考察，采用正交设计法颗粒最佳成型工艺。再对最佳成型颗粒进行临界相对湿度、休止角、溶化性以及颗粒粒度进行测定。[结果] 杏苏止咳颗粒最佳成型辅料为乳糖∶糊精∶可溶性淀粉=1∶3∶1，杏苏止咳干膏粉与辅料按1∶1.20混合均匀，以最佳成型工艺浸膏相对密度1.14、进料速度40 r/min、进风温度为80℃制粒。最佳成型颗粒的临界相对湿度为75.5%，休止角、溶化性以及颗粒粒度均合格。[结论] D-最优混料设计结合正交试验设计建立的模型具有良好的预测性，优选出的工艺稳定可靠，为杏苏止咳颗粒规模化生产提供了可靠依据。

Abstract:

[Objective] To study the optimal prescription of Xingsu Zhike granules and preparation process, and investigate the physical properties and the best shape particles.[Methods] Take the granulating, powder parameters, moisture absorption rate, forming rate and melt investigation as the main index, the single factor investigation for the kinds of molding material; grain moisture absorption rate as index, the D-the optimum mixture design of examining the optimal formula of forming accessories, particle optimal molding process by orthogonal design method. Critical relative humidity on the best forming particles, angle of repose, melting and grain size were determined.[Results] The results of Xingsu Zhike granules best molding materials for soluble starch, dextrin, lactose=1:3:1, Xingsu Zhike granules dry paste powder and supplementary material by 1:1.20 mixing, to extract the best molding process relative density 1.14, 40 r/min 1 feed speed, inlet air temperature of 80℃ granulating. The best forming granular critical relative humidity of 75.5%, angle of repose, melting and grain size are qualified.[Conclusion] The D-optimum mixing design combined with orthogonal experiment design to establish model has good predictability, optimized process is stable and reliable, for the industrialization of Xingsu Zhike granules production provides a reliable basis.