| 摘要: |
| [目的] 系统评价柴胡疏肝散加减方治疗肠易激综合征（IBS）的临床疗效以及安全性。[方法] 检索从建库至2016年10月10日间收录于中国知网（CNKI）、中国生物医学文献数据库（CBM）、维普数据库（VIP）、万方数据库（WanFang）、Pubmed、The Cochrane Library及Embase关于柴胡疏肝散加减方治疗IBS的随机对照试验（RCT），由2人进行质量评价和数据收集，采用RevMan5.3版软件进行评价。[结果] 共纳入11个RCT，包含1 288例患者。Meta分析结果提示：柴胡疏肝散加减方治疗IBS在总有效率、治愈率和显效率方面，均优于常规西医治疗，其中总有效率OR=4.98，95% CI（3.56，6.96），P<0.000 01，治愈率OR=2.19，95% CI（1.49，3.20），P<0.000 1，显效率OR=1.84，95% CI（1.40，2.41），P<0.000 1，且未发现明显不良反应。[结论] 柴胡疏肝散加减方治疗IBS具有较好的疗效，优于常规西药。因纳入文献质量较低，可能存在较大偏倚，故仍需要更多设计更为严谨的大样本临床试验，以期为临床提供更为可靠的循证医学依据。 |
| 关键词: 柴胡疏肝散 肠易激综合征 随机对照试验 Meta分析 |
| DOI：10.11656/j.issn.1672-1519.2017.12.04 |
| 分类号:R574 |
| 基金项目:国家自然科学基金项目（81573775）；上海市卫生系统百人计划基金项目（XBR2013120）；第二批上海市卫生系统学科带头人和优秀青年人才培养计划基金资助项目（沪卫计委科教[2013]9号-50）；上海市科学技术委员会项目（15401930700）。 |
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| A Meta-analysis of randomized controlled clinical study on treating irritable bowel syndrome with modified Chaihu Shugan powder |
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SU Kai-qi, SHEN Yan-ting, LIN Liu-bing, QUE Ren-ye, CHEN Yi-rong, LI Yong
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Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
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| Abstract: |
| [Objective] To evaluate the clinical efficacy and safety of Chaihu Shugan powder in the treatment of irritable bowel syndrome (IBS).[Methods] CNKI, CBM, VIP and Wanfang data, PubMed, The Cochrane Library, Embase were searched for the randomized controlled clinical trials of all Chaihu Shugan powder in the treatment of irritable bowel syndrome, and the time was set from the time when the database was created to October 10, 2016. Meta-analysis was carried out by RevMan 5.3 software, which was used to evaluate the quality of the method and extract valid data.[Results] Eleven studies were eventually included and included a total of 1 288 patients. Meta-analysis showed that Chaihu Shugan powder could significantly improve the total effective rate, markedly effective rate and cure rate in IBS, compared with conventional Western medicine treatment. Total effective rate[OR=4.98, 95% CI(3.56, 6.96), P<0.000 01], cure rate[OR=2.19,95% CI(1.49,3.20), P<0.000 1], significantly effective rate[OR=1.84, 95% CI(1.40, 2.41), P<0.000 1]. And no significant reactions were found.[Conclusion] Chaihu Shugan powder has better clinical efficacy than routine Western medicine in the treatment of irritable bowel syndrome. However, considering that the quality of the literatures is low, there may be a high risk of bias. So more designs contain a large sample of clinical trials are needed in the hope that we can provide a more reliable clinical evidence-based medicine. |
| Key words: Chaihu Shugan powder irritable bowel syndrome randomized controlled trial Meta-analysis |
