辨证论治对血吸虫肝病患者的疗效及肝纤四项的影响效果分析

Efficacy and safety of traditional Chinese medicine differentiating treatment and the liver fibrosis in schistosomiasis liver disease patients

关键词:  血吸虫肝病  辨证论治  疗效  肝纤维化4项

Key words:  schistosomiasis liver disease  TCM differentiating treatment  curative effect  the four items of liver fibrosis

摘要:

[目的] 观察辨证论治对不同证型血吸虫肝病患者的疗效及肝纤维化4项的影响效果。[方法] 将昆山市第二人民医院消化科自2013年8月-2015年8月收治的120例血吸虫肝病患者作为研究对象，根据随机对照原则，分为2组，即观察组予以中医辨证论治治疗+常规治疗，对照组予以常规治疗，每组均60例。观察治疗前后肝功能相关指标以及肝纤维化4项的变化情况，并评定有效率。[结果] 观察组有效率为90.00%，高于对照组（有效率为71.67%），差异具有统计学意义（P<0.05）。治疗前，两组患者的肝功能、肝纤维化4项指标比较，未见统计学差异（P>0.05）；治疗后，与对照组比较，观察组患者的丙氨酸氨基转移酶（ALT）、总胆红素（TBiL）、透明质酸（HA）、Ⅲ型前胶原（PCⅢ）、层黏连蛋白（LN）、Ⅳ型胶原（Ⅳ-C）的水平降低明显，差异均具有统计学意义（P<0.05）。[结论] 辨证论治血吸虫肝病患者可较好改善患者的肝纤维化4项，提高疗效。

Abstract:

[Objective] To explore the efficacy and safety of traditional Chinese medicine (TCM) differentiating treatment and the liver fibrosis in schistosomiasis liver disease patients with different TCM syndromes.[Methods] The 120 schistosomiasis liver disease patients in the The Second People's Hospital of Kunshan were randomly divided into two groups, just as observation group patients were evaluated efficacy and safety of TCM differentiating treatment. Control group patients were adopted normal management, each group included 60 cases. To observed before and after treatment of liver function related indicators, as well as the change of four items of liver fibrosis and evaluation efficiently.[Results] Observation group effective rate was 90.00%. Effective rate was higher than the control group 71.67%, the difference had statistical significance (P<0.05). Before the treatment, two groups of patients with liver function, fibrosis compared four indicators, no statistical difference (P>0.05). After treatment, compared with the control group and observation group of patients with ALT, AST, TBiL and HA, PCⅢ, LN, IV-C significantly, reduce the differences have statistical significance (P<0.05).[Conclusion] TCM differentiating treatment can improve the liver four indicators and curative effect of patients with schistosomiasis liver.