耳穴压豆联合痰瘀双解方治疗冠心病(心绞痛)合并抑郁症的临床观察

Clinical observations about the therapy of combining auricular point pressing bean with prescriptions of stasis-phlegm type to treat the coronary heart disease (angina pectoris) plus depression

关键词:  耳穴压豆  痰瘀双解方  冠心病  抑郁症

Key words:  auricular pressure  prescriptions for stasis-phlegm type  coronary heart disease  depression

摘要:

[目的]采用耳穴压豆疏通经络配合痰瘀双解方治疗冠心病（心绞痛）合并抑郁症，为冠心病（心绞痛）合并抑郁症的临床观察。[方法]采用随机、对照的研究方法，遵循循证医学的研究原则，将符合诊断、纳入标准的患者按照SPSS 19.0生成的随机数字分为对照组和试验组。对照组采用氯吡格雷以抗血小板，阿托伐他汀降脂，β受体阻滞剂，硝酸酯类及阿普唑仑等西药治疗。试验组在对照组基础上联合耳穴压豆及中药痰瘀双解方，以心绞痛评分量表及汉密尔顿抑郁量表评分为疗效评价指标，以血尿常规及肝肾功能为安全性观察指标，评价耳穴压豆联合痰瘀双解方在冠心病（心绞痛）合并抑郁症中应用的疗效及安全性。[结果]两组间治疗前心绞痛量表评分、汉密尔顿抑郁量表分值比较，差异无统计学意义（P>0.05），同组治疗前后比较差异有统计学意义（P<0.05），且试验组优于对照组，差异有统计学意义（P<0.05）。试验组总有效率优于对照组，具有统计学差异（P<0.05）。安全性分级两组差异无统计学意义（P>0.05）。[结论]耳穴压豆配合痰瘀双解方在冠心病（心绞痛）合并抑郁症治疗中可有效降低患者的心绞痛量表评分及汉密尔顿抑郁量表评分，具有良好疗效。治疗中未对肝肾功能、凝血功能造成不良影响，未出现严重不良反应，具有良好安全性。

Abstract:

[Objective] To observe the clinical therapeutic effect about therapy of combining auricular point pressing bean with prescriptions of stasis-phlegm type to treat the coronary heart disease (angina pectoris) plus depression.[Methods] According to the research principle of evidence-based medicine, patients who met the criteria of diagnosis, inclusion and exclusion were random divided into two groups' control group and treatment group according to the random number table method of SPSS19.0. The control group was treated with anti-platelet therapy (clopidogrel), statins (atorvastatin), nitrates, beta blockers, alprazolam and something else for treatment. Besides above treatment, auricular point pressing with bean and prescriptions for stasis-phlegm type was added to the treatment group. Outcome measurements:angina scale and Hamilton Depression Scale score, safety observation indicators:blood test, urine routine, liver function and renal function, both of them were used to evaluate the efficacy and safety of auricular point pressing with bean and prescriptions for stasis-phlegm type to treat the coronary heart disease (angina pectoris) plus depression.[Results] Compared with each other before the treatment, the difference about angina scale and Hamilton Depression Scale scores was not statistically significant (P>0.05), but after treatment, the difference was statistically significant (P<0.05), and the treatment group was better than the control group. The difference was statistically significant (P<0.05). The total effective rate between the two groups shows the same conclusion, and the difference was statistically significant (P<0.05). What's more, the safety grade about two groups had no significant difference (P>0.05).[Conclusion] Auricular point pressing with bean and prescriptions for stasis-phlegm type has good effect on patient who has the coronary heart disease (angina pectoris) plus depression, and it can also reduce the scores of Hamilton Depression Scale and angina scale. This treatment method has no bad influence on patient's coagulation, liver and kidney function. Meanwhile, there is no serious adverse reactions happens, which have been shown the perfect security.