逍遥丸对青年女性无症状性桥本甲状腺炎相关抗体的影响

Effect of Xiaoyao pill on antibodies associated with asymptomatic hashimoto thyroiditis in young women patients

关键词:  桥本甲状腺炎  逍遥丸  青年女性  甲状腺相关抗体

Key words:  hashimoto thyroiditis  Xiaoyao pill  young women  thyroid associated antibodies

摘要:

[目的]观察逍遥丸对青年女性无症状性桥本甲状腺炎相关抗体的影响。[方法]选取80例青年女性无症状性桥本甲状腺炎患者，随机分为对照组和治疗组，每组40例。对照组随访观察，治疗组予逍遥丸8丸/次，3次/d治疗。分别于治疗前及治疗后3月检测两组患者促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）及甲状腺过氧化物酶抗体（TPO-Ab）和甲状腺球蛋白抗体（Tg-Ab）水平，并进行统计分析。[结果]3个月后，治疗组TPO-Ab、TG-Ab水平较治疗前明显下降，差异有统计学意义（P<0.05或P<0.01）。治疗后两组相比，治疗组TSH、TPO-Ab水平低于观察组，差异均具有统计学意义（P<0.05或P<0.01）。[结论]逍遥丸能够稳定青年女性无症状性桥本甲状腺炎患者甲状腺功能，降低TPO-Ab及Tg-Ab水平。

Abstract:

[Objective] To observe the effect of Xiaoyao pills on antibodies associated with asymptomatic hashimoto thyroiditis in young women patients.[Methods] The 80 young women patients with asymptomatic hashimoto thyroiditis were selected and randomly divided into observation group and treatment group, 40 cases in each group. The observation group was only followed up, the treatment group received Xiaoyao pills,8 pills once, three times daily.Both groups were detected thyroid stimulating hormone (TSH), free triiodothyronine(FT3), free thyroxin (FT4) and thyroid peroxidase antibody (TPO-Ab), thyroglobulin antibody (Tg-Ab) before and after treatment, and the data were analyzed statistically.[Results] The levels of TPO-Ab and TG-Ab in treatment group were significantly lower than those before treatment(P<0.05 or P<0.01). Compared with two groups after treatment, the level of TSH and TPO-Ab in treatment group were both lower than those in observation group, both the difference had statistical significance (P<0.05 or P<0.01).[Conclusion] Xiaoyao pills can keep thyroid function stable and reduce the TPO-Ab and Tg-Ab level in young women patients.