疏阳化痰方对焦虑女性痤疮(阳郁痰凝证)患者疗效及血清炎性因子的影响

Effect of Shuyang Huatan Fang on the efficacy and serum inflammatory factors in patients with anxiety female acne (yang depression phlegm coagulation syndrom)

关键词:  疏阳化痰方  焦虑  痤疮  阳郁痰凝  临床观察

Key words:  Shuyang Huatan Fang  anxiety  acne  yang depression phlegm coagulation syndrom  clinical observation

摘要:

[目的]观察疏阳化痰方治疗焦虑痤疮女性患者80例疗效及对血清炎性因子影响。[方法]纳入2017年1月-2018年1月期间治疗的焦虑女性痤疮患者80例，随机分为治疗组和对照组，每组各40例，对照组常规给予丹参酮胶囊口服，治疗组在对照组基础上给予疏阳化痰方治疗，连续治疗12周；观察治疗前后两组治疗有效率、焦虑评分量表（SAS）、皮肤病生活质量指数（DLQI）、血清炎性因子[白介素-1α（IL-1α）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）]、血清激素水平黄体激素水平（LH）与雌二醇（E₂）、中医证候量表不良反应。[结果]1）治疗后治疗组缓解率为92.5%，对照组缓解率为85.0%，两组在缓解率方面对比无统计学意义（P>0.05）；2）两组治疗后痤疮国际改良分级等级分级比较无统计学差异（P>0.05）；3）两组治疗后DLQI评分、中医证候量表评分、SAS评分对比具有统计学差异（P<0.05）；4）两组治疗前后血清炎性因子（IL-1α、IL-6、TNF-α）、血清激素水平LH与E₂水平变化比较具有统计学差异（P<0.05）；两组治疗前后均未出现不良反应。[结论]疏阳化痰方联合丹参酮胶囊治疗焦虑女性患者痤疮（阳郁痰凝证）效果显著，值得临床应用推广。

Abstract:

[Objective] To observe the clinical efficacy and serum inflammatory factors in 80 female patients with anxiety and acne treated by Shuyang Huatan Decoction.[Methods] From January 2017 to January 2018,80 female acne patients with anxiety were randomly divided into treatment group and control group. The treatment group was 40 cases,the control group was 40 cases,the control group was given tanshinone Capsules orally,the treatment group was treated with Shuyang Huatan Fang on the basic treatment of the control group for 12 weeks. Efficiency,anxiety scale (SAS),dermatosis quality of life index (DLQI),serum inflammatory factors (IL-1α,IL-6,TNF-α),serum hormone level luteal hormone level (LH),estradiol (E₂) and TCM Syndrome Scale adverse reactions in two groups treated before and after the treatment were observed.[Results] 1) After the treatment,the remission rate of the treatment group was 92.5%,the control group was 85.0%,and the two groups had no statistical significance(P>0.05). 2) After the treatment,the two groups had no statistical significance in acne international modified grading system score (P>0.05). 3) After the treatment,DLQI score,TCM Syndrome Scale score and anxiety scale score (SAS) had statistical significance (P<0.05). 4) Compared with the before treatment,the changes of serum inflammatory factors(IL-1α,IL-6,TNF-α),serum hormone level luteal hormone level(LH) and estradiol E₂ levels in the two groups had statistical significance after the treatment(P<0.05). There was no adverse reaction before and after treatment in two groups.[Conclusion] Shuyang Huatan Fang Combined with tanshinone Capsules was effective in the treatment of anxiety female patients with acne yang depression phlegm coagulation syndrom. It is worthy of clinical application and promotion.