解郁丸联合帕罗西汀治疗卒中后抑郁临床疗效研究

Study on the clinical efficacy of Jieyu Pill combined with paroxetine in the treatment of post-stroke depression

关键词:  卒中后抑郁  解郁丸  负面情绪  前瞻性队列研究

Key words:  post-stroke depression  Jieyu Pill  negative emotion  prospective cohort study

摘要:

[目的]通过前瞻性队列研究观察解郁丸联合帕罗西汀治疗中风后抑郁的临床疗效及安全性。[方法]选取自2017年1月-2018年9月期间住院的360名符合纳入、排除标准及患者是否接受中医治疗分为观察组和对照组，对照组给予住院基础治疗、康复治疗及帕罗西汀抗抑郁治疗，观察组在对照组基础上给予解郁丸口服治疗，干预前后对两组患者的美国国立卫生院神经功能缺损评分量表（NIHSS）、汉密尔顿抑郁量表（HAMD）、抑郁自评量表（SDS）、安全性指标进行比较。[结果]两组患者分别于干预1个月、3个月后行NIHSS评分、HAMD评分、SDS量表评分较治疗前评分均降低；干预1个月后两组组间比较、组内比较NIHSS评分、HAMD评分、SDS评分差异均无统计学差异（P>0.05）；两组干预3个月后NIHSS、HAMD、SDS评分组内比较、组间比较差异均具有统计学意义（P<0.05）。治疗3个月后实验组患者临床总有效率为90.00%，对照组总有效率为78.33%，两组总有效率比较，差异具有统计学意义（P<0.05）。[结论]解郁丸联合帕罗西汀组治疗中风后抑郁临床疗效优于单纯帕罗西汀组。

Abstract:

[Objective] To observe the clinical efficacy and safety of Jieyu Pill combined with paroxetine in the treatment of post-stroke depression by prospective cohort study.[Methods] This study selected 360 patients who were hospitalized from January 2017 to September 2018 who met the inclusion and exclusion criteria. The patients were divided into the experimental group and the control group according to whether the patients accept Chinese medicine treatment. The control group was given basic medical treatment,rehabilitation treatment and paroxetine antidepressant treatment,and the observation group was given oral treatment of Jieyu Pill on the basis of the control group. Before and after intervention,the safety indexes of the National Institutes of Health Neurological Deficit Score (NIHSS),Hamilton Depression Scale (HAMD) and Self-rating Depression Scale (SDS) were compared between the two groups.[Results] The NIHSS score,HAMD score,and SDS scale scores of patients in the two groups were lower at 1 month and 3 months after intervention than those before treatment. After 1 month of intervention,there was no significant difference in NIHSS scale score,HAMD scale score and SDS scale score between the two groups (P>0.05); and after intervention for 3 months,there were statistically significant differences between the two groups in the evaluation of all scores (P<0.05). The total clinical effective rate was 90.00% in the treatment group after three months,which was significantly higher than 83.89% in the control group (P<0.05).[Conclusion] The clinical efficacy of Jieyu Pill combined with paroxetine in the treatment of post-stroke depression was better than that of paroxetine alone.