微/纳米口服结肠靶向给药系统在炎症性肠病治疗中的研究进展

Advances in the study of micro/nano oral colonic targeted delivery system in the treatment of inflammatory bowel disease

关键词:  微/纳米颗粒  炎症性肠病  胃肠道生理因素  结肠靶向  结肠递送系统

Key words:  micro/nano particle  inflammatory bowel disease  physiological factor of gastrointestinal tract  colon targeting  colonic delivery system

摘要:

口服结肠靶向给药系统（OCTDDS）被设计用于将治疗剂靶向递送至结肠疾病部位，以改善药物治疗效果，降低全身不良反应，提高生物利用度，对于炎症性肠病（IBD）的治疗十分有利。然而，疾病状态下，胃肠道的生理环境改变会影响药物的治疗功效。临床常用的治疗IBD的药物长期服用会导致严重的全身性不良反应，中药作为其补充和替代药物，吸引了越来越多研究者的关注。近年来，微米和纳米颗粒因其相对适宜的粒径、较长的药物滞留时间、可控的药物吸收率等优势，逐渐成为治疗IBD的有效工具，文章主要综述影响药物口服递送的胃肠道生理因素，微/纳米制剂的剂型设计和药效作用研究进展，旨在为口服生物利用度低的药物的结肠靶向递送提供参考。

Abstract:

The oral colon-targeted drug delivery system (OCTDDS) is designed to target the delivery of therapeutic agents to colonic disease sites to improve the effectiveness of drug treatment,reduce systemic side effects,increase bioavailability,which is beneficial for the treatment of inflammatory bowel disease (IBD). However,in a disease state,changes in the physiological environment of the gastrointestinal tract can affect the therapeutic efficacy of the drug. The long-term use of commonly used drugs for the treatment of IBD in clinical practice can cause serious systemic side effects. As a supplement and alternative medicine,Chinese medicine has attracted more and more researchers' attention. In recent years,micro-particles and nano-particles have gradually become effective tools for the treatment of IBD due to their relatively suitable particle size,long drug retention time,and controllable drug absorption rate. This article mainly reviews the physiological factors of gastrointestinal tract that affects oral drug delivery,the formulation design of micro/nano preparations and the research progress of pharmacodynamic effect to provide a reference for colonic targeted delivery of drugs with low oral bioavailability.