补骨脂“雷公炮制法”减毒的科学内涵

Scientific connotation of attenuation of Psoralea corylifolia by “Leigong processing method”

关键词:  补骨脂  雷公炮制法  化学成分  肝毒性  减毒机制

Key words:  Psoralea corylifolia  Leigong processing method  chemical component  hepatotoxicity  attenuation mechanism

摘要:

补骨脂是临床常用的补益类中药，具有补肾壮阳、补脾健胃的功能。补骨脂生品性燥，具有较强的肝毒性，因此临床使用上多以其炮制品为主。补骨脂炮制最初见于《雷公炮炙论》，后世医药学家在医疗实践中继承并发展了雷公炮制法。在课题组前期研究的基础上，结合2020年之前发表的与补骨脂相关的文献，通过炮制前后化学成分的变化分析补骨脂“雷公炮制法”的减毒机制，发现雷公法炮制过程中补骨脂毒性成分（异）补骨脂苷转化为活性成分（异）补骨脂素，阐述了雷公炮制法减毒的科学内涵，为进一步优化补骨脂炮制工艺提供科学依据。

Abstract:

Psoralea corylifolia is a kind of tonic traditional Chinese medicine commonly used in clinic,which has the functions of tonifying kidney and strengthening yang,invigorating spleen and strengthening stomach. Raw Psoralea corylifolia is dry and has strong hepatotoxicity. Therefore,its processed products are mainly used in clinic. The processing of Psoralea corylifolia was first seen in Leigong paozhilun,and later medical scientists inherited and developed the Leigong processing method in medical practice. Based on the previous research by the research group,combined with the literature related to Psoralea corylifolia published before 2020,this paper analyzes the attenuation mechanism of Psoralea corylifolia by “Leigong processing method” through the changes of chemical components before and after processing. It found that the toxic component (iso) psoralenoside is transformed into the active component (iso) psoralen in the processing process of Leigong processing method. This expounds the scientific connotation of attenuation of Psoralea corylifolia by Leigong processing method and provides scientific basis for further optimizing the processing technology of Psoralea corylifolia.