灸法对结直肠癌癌因性疲乏的疗效及免疫功能的影响

Effect of moxibustion on cancer-related fatigue and immune function in colorectal cancer

关键词:  灸法  结直肠癌癌因性疲乏  淋巴细胞亚群  绝对计数

Key words:  moxibustion  cancer-related fatigue in colorectal cancer  lymphocyte subsets  absolute count

摘要:

[目的] 观察以灸法治疗结直肠癌癌因性疲乏的疗效及其对淋巴细胞绝对计数的影响。[方法] 将符合纳入、排除标准的气虚证结直肠癌癌因性疲乏的患者随机分为两组，对照组应用常规治疗，治疗组应用常规治疗联合灸法治疗，观察治疗前后两组的Piper量表、卡氏（KPS）评分、淋巴细胞亚群百分比及绝对计数的变化。[结果] 对照组治疗前后的Piper量表中行为维度明显下降、淋巴细胞亚群CD8⁺细胞百分比明显下降，其余诸项无统计学变化；治疗组治疗前后的KPS评分明显升高，Piper量表中行为维度、情绪维度、感觉维度、总分评分明显降低，淋巴细胞亚群CD4⁺细胞百分比和绝对计数明显升高，其余诸项无统计学变化。[结论] 灸法后可明显缓解气虚证结直肠癌患者的疲乏状态、提高生活质量，其作用机制可能通过提高淋巴细胞、改善免疫功能来实现的，这种简便易行、确有疗效的方法为临床治疗该类病症提供了很好的思路。

Abstract:

[Objective] To observe the curative effect of moxibustion on cancer-related fatigue of colorectal cancer and the influence of absolute lymphocyte count.[Methods] Patients with cancer-related fatigue of colorectal cancer with qi deficiency syndrome were randomly divided into two groups. The control group was treated with conventional therapy,while the treatment group was treated with conventional therapy combined with moxibustion. The changes of Piper scale,KPS score,percentage of lymphocyte subsets and absolute count of the two groups were observed before and after treatment.[Results] Before and after treatment,the Piper scale in the control group showed significant decrease in behavioral dimension and percentage of CD8⁺ cells in lymphocyte subgroup,but no significant change in other items. KPS score in the treatment group increased significantly before and after treatment,the behavioral dimension,emotional dimension,sensory dimension and total score of piper scale decreased significantly,the percentage of CD4⁺ cells and absolute count of lymphocyte subsets increased significantly,and the remaining items showed no significant changes.[Conclusion] Moxibustion can obviously relieve the fatigue and improve the quality of life of colorectal cancer patients with qi deficiency syndrome,and its mechanism may be realized by improving lymphocytes and immune function. This simple and effective method provides a good idea for clinical treatment of this kind of disease.