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| 多指标综合加权评分法优选复方夏枯草洗剂提取工艺研究 |
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陆雪琴1, 赵亮2,3, 周洁1, 段彦娟1, 张春燕3, 朱建勇3, 翟晓翔1,2
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1.上海中医药大学附属第七人民医院皮肤科, 上海 200137;2.南京中医药大学, 南京 210023;3.上海中医药大学附属第七人民医院中心实验室, 上海 200137
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| 摘要: |
| [目的] 优选复方夏枯草洗剂的提取工艺。[方法] 采用L9（34）正交设计，以迷迭香酸、丹酚酸B的含量及出膏率的综合评分为指标，考察料液比、提取时间、提取次数对提取效果的影响，优选复方夏枯草洗剂的最佳提取工艺。[结果] 根据综合评分的结果，优选出最佳提取工艺为加8倍水，提取3次，每次0.5 h。[结论] 该工艺准确可靠，可行性好。 |
| 关键词: 复方夏枯草洗剂 正交实验 迷迭香酸 丹酚酸B 综合加权评分法 |
| DOI：10.11656/j.issn.1672-1519.2020.12.23 |
| 分类号:R284.2 |
| 基金项目:2018年度浦东新区“国家中医药发展综合改革试验区”建设项目（PDZY-2018-0803）；国家自然科学基金青年基金项目（8150140723）；上海市卫生和计划生育委员会科研项目（20194Y0424）；浦东新区卫生和计划生育委员会临床中医高原学科建设项目（PDZT-2018-0604）。 |
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| Optimizing extraction process of Compound Xiakucao Lotion by comprehensive evaluation of multiple mark |
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LU Xueqin1, ZHAO Liang2,3, ZHOU Jie1, DUAN Yanjuan1, ZHANG Chunyan3, ZHU Jianyong3, ZHAI Xiaoxiang1,2
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1.Department of Dermatology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China;2.Nanjing University of Chinese Medicine, Nanjing 210023, China;3.Central Laboratory, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
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| Abstract: |
| [Objective] To investigate the extraction process of Compound Xiakucao Lotion.[Methods] Orthogonal test was used to investigate effects of solid-liquid ratio,extraction time,and times on extraction process.The extraction process was optimized by comprehensive evaluation indexes based on the content of rosmarinic acid,salvianolic acid B,and the extraction yield.[Results] According to the result of comprehensive score,the optimal extraction conditions of this preparation were as follows:extracted twice with 8 times of water quantity,each for half one hour.[Conclusion] The optimized process is accurate,reliable and feasible for the industrial production of Compound Xiakucao Lotion. |
| Key words: Compound Xiakucao Lotion orthogonal experiment rosmarinic acid salvianolic acid B comprehensive evaluation of multiple mark |
