三部推拿开窍法联合康复训练治疗孤独症谱系障碍患儿的临床疗效观察及作用机制探究

Clinical observation and mechanism of “three part massage and resuscitation method” combined with rehabilitation training in the treatment of children with autism spectrum disorders

关键词:  推拿  孤独症谱系障碍  ATEC  t-PA  PAI-1

Key words:  massage  autism spectrum disorder  ATEC  t-PA  PAI-1

摘要:

[目的] 探讨“三部推拿开窍法”对孤独症谱系障碍患儿行为、语言、社交等干预作用并对其作用机制进行探究。[方法] 取2016年1月至2019年3月河南中医药大学第一附属医院孤独症患儿96例按简单随机数字表法随机分为对照组（48例），观察组（48例）。对照组行常规康复训练，观察组在常规康复训练的基础上联合三部推拿开窍法进行治疗，分别于治疗6月后进行疗效观察并孤独证治疗评估量表（ATEC）量表评估及组织型纤溶酶原激活剂（t-PA）、血浆纤溶酶原激活物（PAI-1）指标检测。[结果] 1）两组治疗后与治疗前相比均呈明显的下降趋势，有统计学差异（P<0.05），治疗6月后观察组ATEC评分与对照组之间比较有统计学差异（P<0.05），且观察组优于对照组。2）血清t-PA及PAI-1水平治疗前后比较均有统计学差异（P<0.05），t-PA水平呈明显的上升趋势，PAI-1呈明显的下降趋势，治疗6月后观察组t-PA及PAI-1水平与对照组之间比较有统计学差异（P<0.05），且观察组优于对照组。[结论] “三部推拿开窍法”联合康复训练能有效改善孤独症患儿的行为、语言、社交等功能，改善患儿的临床症状。

Abstract:

[Objective] To explore the intervention effect of "three part massage and resuscitation method" on behavior, language and social interaction of children with autism spectrum disorders, and to explore its mechanism based on the theory of traditional Chinese medicine.[Methods] From January 2016 to March 2019, 96 children with autism in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine were selected. The control group (48 cases) received routine rehabilitation training. The observation group (48 cases) was treated on the basis of routine rehabilitation training combined with three part massage and resuscitation. After 6 months of treatment, the curative effect was observed and the ATEC scale and t-PA and PAI-1 indexes were evaluated.[Results] 1)After treatment, the observation group and the control group showed a significant downward trend compared with before treatment, with statistical difference (P<0.05). After 6 months of treatment, there was a significant statistical difference between the observation group and the control group (P<0.05), and the observation group was better than the control group. 2)The serum t-PA and PAI-1 levels before and after treatment were statistically different (P<0.05), and the t-PA level showed a significant upward trend, and the PAI-1 showed a significant downward trend. After 6 months of treatment, the level of t-PA and PAI-1 in the observation group was significantly different from that in the control group (P<0.05), and the observation group was better than the control group.[Conclusion] "Three part massage and resuscitation method" combined with rehabilitation training can effectively improve the behavior, language, social and other functions of children with autism, and improve the clinical symptoms of children.