基于胃肠激素水平变化探讨调理脾胃针法治疗糖尿病性胃轻瘫的疗效机制

Explore the therapeutic mechanism of regulating spleen and stomach acupuncture on diabetic gastroparesis based on the changes of gastrointestinal hormones

关键词:  胃肠激素  调理脾胃针法  糖尿病性胃轻瘫  针刺研究  临床研究

Key words:  gastrointestinal hormones  regulating spleen and stomach acupuncture  diabetic gastroparesis  acupuncture research  clinical research

摘要:

[目的] 观察调理脾胃针法治疗糖尿病性胃轻瘫的临床疗效，探讨其对胃肠激素水平的影响。[方法] 将符合纳入标准的70例糖尿病性胃轻瘫患者按照随机数字表法随机分为观察组、对照组各35例。两组患者在糖尿病基础治疗的同时，对照组口服枸橼酸莫沙必利分散片5 mg，每日3次，餐前口服，观察组采用调理脾胃针法，取穴：中脘、足三里、阴陵泉、血海、三阴交、地机、曲池、合谷、丰隆、太冲、内关、公孙。连续治疗6周。分别于治疗前后对临床症状评分、综合疗效、跨膜蛋白16A（ANO1）、胃肠激素水平进行评定，将结果进行统计学分析。[结果] 观察组临床总有效率为88.57%，对照组为68.57%，在胃轻瘫主要症状评定方面两组治疗方法均可以提高患者各症状积分及总体症状积分，但在嗳气、腹胀、食欲不振、恶心呕吐、总体症状积分、ANO1及胃肠激素水平改善方面，观察组优于对照组（P<0.01）。[结论] 调理脾胃针法可明显改善糖尿病性胃轻瘫患者的临床症状，提高总有效率，降低ANO1含量，改善胃肠激素水平，其疗效优于单纯西药，且安全可靠。

Abstract:

[Objective] To observe the clinical effect of regulating spleen and stomach acupuncture on diabetic gastroparesis and to explore its effect on gastrointestinal hormone level.[Methods] The 70 patients with diabetic gastroparesis who met the inclusion criteria were randomlydivided into observation group and control group by random number table method. At the same time of diabetic basic treatment. The conerol group received oral mosapride cirate dispersible tablets 5 mg,three times per day,oral before meal. Patients in the treatment group were treated by regulating spleen and stomach acupoints in the observation group:zhongwan(RN12),zusanli(ST36),yinlingquan(SP9),xuehai(SP10),sanyinjiao(SP6),diji(SP8),quchi(LI11),hegu(LI4),fenglong(ST40),taichong(LR3),neiguan(PC6),gongsun(SP4). Two groups were continuous treatment for 6 weeks. Clinical symptom score,comprehensive efficacy evaluation,transmembrane protein 16A (ANO1) and gastrointestinal hormone levels were assessed before and after treatment,and the results were statistically analyzed.[Results] Clinical observation group the total effective rate was 88.57%,the control group was 68.57%,the main symptoms of gastroparesis evaluation on patients with two groups of treatment can improve the symptoms and general symptoms integral,but in the gas,bloating,loss of appetite,nausea,vomiting,general symptoms integral,16 A transmembrane protein and gastrointestinal hormone levels improve,observation group is better than that of control group (P<0.01).[Conclusion] The method of regulating spleen and stomach acupuncture can obviously improve the clinical symptoms of diabetic gastroparesis patients,improve the total effective rate,reduce the content of ANO1 and improve the level of gastrointestinal hormones. Its curative effect is superior to that of Western medicine treatment,and it is safe and reliable.