血必净注射液联合奥曲肽对重症急性胰腺炎患者胰腺血流灌注及血流动力学的影响

Effects of Xuebijing Injection combined with octreotide on pancreatic blood perfusion and hemodynamics in patients with severe acute pancreatitis

关键词:  重症急性胰腺炎  奥曲肽  血必净注射液  血流灌注  血流动力学

Key words:  severe acute pancreatitis  octreotide  Xuebijing Injection  blood perfusion  hemodynamics

摘要:

[目的] 探讨血必净注射液联合奥曲肽对重症急性胰腺炎患者胰腺血流灌注及血流动力学的影响。[方法] 选取2016年2月—2019年10月本院收治的重症急性胰腺炎患者（100例）进行随机对照单盲研究，按电脑数字表法随机分为两组，各50例，对照组患者采用奥曲肽和生理盐水治疗，观察组患者采用奥曲肽和血必净注射液治疗，疗程7 d。对比两组患者的临床疗效、相关疗效指标、胰腺血流灌注的改变以及血流动力学指标等。[结果] 血淀粉酶恢复到正常数值的时间（6.25±2.13）d、腹痛消失的时间（4.03±1.21）d以及胃肠减压的时间（5.13±2.15）d，观察组所用的相对较小（P<0.05）；观察组患者治疗后血流量（BF）为（3.46±0.60）mL·min/g、血容量（BV）为（0.30±0.06）mL/g、平均通过时间（MTT）为7.85±1.24）s、表面通透性（PS）为（0.30±0.04）mL·min/g等胰腺血流灌注指标明显优于对照组（P<0.05）；入院后5、7 d两组平均动脉压（MAP）、中心静脉压（CVP）、心率（HR）等指标均明显改善，随着治疗时间的延长改善越明显，观察组明显优于对照组（P<0.05）。[结论] 在对重症急性胰腺炎病患者进行治疗的过程中，使用血必净注射液和奥曲肽进行联合治疗，具有较好的临床效果，有利于患者的预后，值得临床推广。

Abstract:

[Objective] To investigate the effect of Xuebijing Injection combined with octreotide on pancreatic blood perfusion and hemodynamics in patients with severe acute pancreatitis.[Methods] Patients with severe acute pancreatitis (100 cases) admitted to our hospital from February 2016 to October 2019 were selected and randomly divided into two groups according to computer-generated number table method to research randomized controlled single blind,with 50 cases of patients in each group. Patients in the control group were treated with octreotide and physiological saline,and the observation group was given octreotide and Xuebijing Injection,all treated 7 days. The clinical efficacy,related efficacy indicators,changes in pancreatic blood perfusion,and hemodynamic parameters were compared between two groups.[Results] In the comparison of the time when the blood amylase returned to the normal value (6.25±2.13) d,the time when the abdominal pain disappeared (4.03±1.21) d,and the time of the gastrointestinal decompression (5.13±2.15) d,the time used by the observation group was relatively short (P<0.05). The pancreatic blood perfusion index of the patients in the observation group were better than that in the control group including blood flow (BF),(3.46±0.60) mL·min/g,blood volume (BV),(0.30±0.06) mL/g,mean transit time (MTT),(7.85±1.24) s,Permeability Surface area product(PS),(0.30±0.04) mL·min/g (P<0.05). MAP,CVP,HR were significantly improved after treated 5 days,7 days,and the improvement was more obvious with the prolongation of treatment time. The observation group was significantly better than the control group (P<0.05).[Conclusion] In the treatment of patients with severe acute pancreatitis,the combination of Xuebijing and octreotide has a good clinical effect,which is beneficial to patients. Prognosis is worthy of clinical promotion.