调更汤对更年期女性记忆能力影响的临床研究

Clinical study on the effect of Tiaogeng Decoction on the memory ability of menopausal women

关键词:  调更汤  记忆商  认知功能下降  阿尔茨海默症

Key words:  Tiaogeng Decoction  memory quotient  cognitive decline  Alzheimer's disease

摘要:

[目的] 观察调更汤对更年期女性记忆能力的影响。[方法] 80例记忆能力明显减退的更年期综合征患者随机分为治疗组及对照组，每组各40例，治疗组给予中药调更汤治疗，对照组给与补佳乐结合黄体酮胶囊人工周期治疗，疗程为12周。[结果] 治疗组完成观察38例，对照组完成观察37例，两组治疗后与治疗前比较对更年期综合征患者改良KI评分均有明显改善（P<0.01），治疗后两组疗效无统计学差异（P>0.05）。两组治疗后患者记忆商均有提高，治疗组优于对照组，差异有统计学意义（P<0.01）。两组血清雌二醇（E2），黄体生成素（LH）水平比较，对照组治疗后与治疗前比较差异有统计学意义（P<0.01）。[结论] 调更汤可提高更年期记忆能力下降患者的记忆商，改善记忆能力。根据中医治未病思想，更年期记忆能力的改善有望降低认知功能下降的发生，从而有可能降低女性阿尔茨海默症的发病。

Abstract:

[Objective] To observe the effect of Tiaogeng Decoction on the memory ability of menopausal women.[Methods] The 80 patients with perimenopausal syndrome were randomly divided into treatment group and control group,40 cases in each group. The treatment group was treated with Tiaogeng Decoction,while the control group was treated with estradiol valerate combined with progesterone capsule for 12 weeks.[Results] There were 38 cases in the treatment group and 37 cases in the control group. Compared with before treatment,the improved KI scores of the two groups were significantly improved (P<0.01),and there was no significant difference between two groups after treatment (P>0.05). After treatment,the memory quotient of the two groups were improved,and the treatment group was better than that in the control group,and had statistical difference (P<0.01). The level of serum E2,LH in the control group after treatment was significantly higher than that before treatment (P<0.01)[Conclusion] Tiaogeng Decoction can improve the memory quotient and memory ability of menopausal patients with memory decline. According to the thought of preventive treatment of disease in traditional Chinese Medicine,the improvement of menopausal memory ability is expected to reduce the occurrence of cognitive decline,which may reduce the incidence of female Alzheimer's disease.