基于血浊理论探讨Wilson病的辨治

Discussion on differentiation and treatment of Wilson disease based on the theory of blood turbidity

关键词:  Wilson病  肝豆状核变性  血浊  清化血浊

Key words:  Wilson disease  hepatolenticular degeneration  blood turbidity  clearing blood turbidity

摘要:

Wilson病是一种常染色体隐性遗传的铜转运障碍疾病，临床表现以肝病和神经系统症状最为常见，是少数具有有效治疗手段的遗传疾病之一。目前以青霉胺（PCA）为代表的金属络合剂驱铜治疗方法在临床应用上存在一定的局限性，使其适用人群和治疗效果受到限制。在西医对Wilson病认识的基础上，结合王新陆教授的血浊理论可知，Wilson病的中医病因病机责之先天不足，肝肾亏虚，铜毒内聚，酿生血浊。根据血浊理论可以清化血浊法治之。

Abstract:

Wilson disease is an autosomal recessive disorder of copper transport. Liver disease and nervous system symptoms are the most common clinical manifestations,and it is one of the few genetic diseases with effective treatment. At present,the metal complexing agent represented by penicillamine (PCA) has some limitations in clinical application,which limits its applicable population and therapeutic effect. On the basis of Western medicine's understanding of Wilson disease,combined with Professor WANG Xinlu's theory of blood turbidity,the etiology and pathogenesis of Wilson disease can be attributed to congenital deficiency,deficiency of liver and kidney,cohesion of copper and toxin,and blood turbidity caused by brewing. According to the theory of blood turbidity,clearing blood turbidity might be a new method to treat Wilson disease.