| 摘要: |
| 多糖是人类膳食的重要组成，具有丰富的生物活性。胆汁酸是肠道脂类消化液的主要成分，也是代谢稳态关键信号因子，对机体健康具有重要影响，研究表明一些活性多糖可调控体内胆汁酸的水平。胆汁酸经肠道被重吸收、代谢与排泄，多糖发挥生物活性也与肠道密切相关。文章从多糖调控肠道胆汁酸转运体、调节肠道菌群、直接结合胆汁酸等方面，综述活性多糖通过肠道调节胆汁酸的研究进展。 |
| 关键词: 多糖 胆汁酸 肠道 肠道菌群 胆汁酸转运体 |
| DOI：10.11656/j.issn.1672-1519.2022.01.28 |
| 分类号:R574 |
| 基金项目:国家自然科学基金重点项目（81803959）；天津市自然科学基金项目（19JCYBJC28500）；国家“重大新药创制”科技重大专项（2018ZX09735-002）。 |
|
| Active polysaccharides regulating bile acids throughintestinal tract |
|
DI Jingrui, SHANG Fei, YANG Li, YANG Miaojie, ZHAO Xin, ZHANG Peng
|
|
The State Key Laboratory of Component-based Chinese Medicine, Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
|
| Abstract: |
| Polysaccharides are important component of human diet and have rich biological activities. Bile acids are the major component of intestinal lipid digestibility and the key signaling factor of metabolic homeostasis，which have crucial impact on human health. Studies have shown that some active polysaccharides can regulate the level of bile acids in vivo. Bile acids are reabsorbed，metabolized and excreted through the intestine，and the biological activities of polysaccharides are also closely related to the intestinal tract. This article reviews the research progress of active polysaccharides regulating bile acids from the aspects of adjusting intestinal bile acid transporters，regulating gut microbiota and binding directly to the bile acids. |
| Key words: polysaccharide bile acid intestine intestinal flora bile acid transporter |
