| 摘要: |
| 女贞子为木犀科植物女贞Ligustrum lucidum Ait. 的干燥成熟果实。女贞子中的多糖、三萜、环烯醚萜以及黄酮类化合物能够通过增强胰岛素敏感性、改善胰岛素抵抗、保护胰岛β细胞；调控激活腺苷酸活化蛋白激酶（AMPK）、蛋白激酶B（AKT）、蛋白酪氨酸磷酸酶1B（PTP1B）信号通路；调节免疫、抑制炎症因子的释放以及抗氧化等作用改善糖脂代谢紊乱。本研究通过系统的文献检索、综述女贞子调节代谢紊乱的物质基础并分析其可能作用机制，为女贞子调节糖脂代谢性疾病提供参考。 |
| 关键词: 女贞子 糖脂代谢 作用机制 |
| DOI：10.11656/j.issn.1672-1519.2022.04.24 |
| 分类号:R285.5 |
| 基金项目:重大新药创制项目（2019ZX09201005-002-007）；天津市科技计划项目（19ZYPTJC00060）。 |
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| Research progress of chemical constituents and pharmacological activities of Ligustri Lucidi Fructus in improving glucose and lipid metabolic disorders |
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WANG Weiqiang1, ZHU Tongtong1, DAI Yongna2, GAO Zhijie1, FU Zhifei1, LIU Erwei1
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1.Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.Clinical Expertise Training Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Ligustri Lucidi Fructus is the dried and mature fruit of Ligustrum lucidum Ait,which belongs to the Oleaceae family. Polysaccharides,triterpenes,secoiridoids and flavonoids in Ligustri Lucidi Fructus can enhance insulin sensitivity,improve insulin resistance,and protect pancreatic β cells. They can regulate AMPK,AKT and PTP1B pathways. They can regulate immunomodulatory,inhibit the release of inflammatory factors and antioxidation which improves glucose and lipid metabolic disorders. In this study,based on systematic literature and books,we summarize the chemical constituents and pharmacological activities of Ligustri Lucidi Fructus in improving glucose and lipid metabolic disorders,and possible active mechanisms,which provides reference for further usage of Ligustri Lucidi Fructus in treating glycolipid metabolic diseases. |
| Key words: Ligustri Lucidi Fructus glucose and lipid metabolism bioactivity mechanism |
