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| GPX4在心血管疾病中的作用及中药干预研究进展 |
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杨昕彤1, 张悦1, 刘思夏1, 冷玲1,2, 黎瑞巧1,2, 王启隆1,2,3
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1.天津中医药大学中医药研究院, 天津 301617;2.组分中药国家重点实验室, 天津 301617;3.现代中医药海河实验室, 天津 301617
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| 摘要: |
| 谷胱甘肽过氧化物酶4（GPX4）是细胞抗氧化系统的关键调节酶，可以抑制细胞内脂质过氧化和铁死亡，在动脉粥样硬化、心肌缺血再灌注等心血管疾病发生发展中起重要作用。文章在治疗心血管疾病中具有明显的优势，其机制可能与调节GPX4，抑制细胞氧化应激、脂质过氧化和铁死亡有关。文章以GPX4为切入点，旨在阐明GPX4在心血管疾病中扮演的角色以及中药通过GPX4防治心血管疾病的机制，为心血管疾病治疗及药物开发提供潜在的治疗靶点。 |
| 关键词: 心血管疾病 谷胱甘肽过氧化酶4 中药 功能 方剂 |
| DOI：10.11656/j.issn.1672-1519.2023.02.21 |
| 分类号:R54 |
| 基金项目:国家自然科学基金资助项目（81973624）；天津市科技计划项目（21ZYJDJC00070）；国家重点研发计划“中医药现代化”重点专项项目（2019YFC1708803）；国家中医药管理局中医药创新团队及人才支持计划项目（ZYYCXTD-C-202203）。 |
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| Role of GPX4 in cardiovascular disease and research progress of traditional Chinese medicine intervention |
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YANG Xintong1, ZHANG Yue1, LIU Sixia1, LENG Ling1,2, LI Ruiqiao1,2, WANG Qilong1,2,3
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1.Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education, Tianjin 301617, China;3.Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Glutathione peroxidase 4(GPX4) is a crucial enzyme of the cellular antioxidant system and can inhibit intracellular lipid peroxidation and ferroptosis. Regulation of GPX4 activity has become therapeutically attractive,particularly in cardiovascular diseases such as atherosclerosis and myocardial ischemia-reperfusion. Traditional Chinese medicine(TCM) has apparent advantages in treating cardiovascular diseases. TCM-based mechanisms may be related to the regulation of GPX4 and inhibition of cellular oxidative stress,lipid peroxidation,and ferroptosis. In this review,GPX4 is used as an entry point to elucidate the role of GPX4 in cardiovascular diseases and to understand how TCM modulates GPX4 activity to prevent cardiovascular disease development or progression,so as to provide potential therapeutic targets for the treatment of cardiovascular diseases and drug development. |
| Key words: cardiovascular diseases GPX4 traditional Chinese medicine function prescription |
