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| 神经病理性疼痛的小胶质-星形胶质细胞串扰机制及中医药治疗研究进展 |
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陈雨钊1,2,3,4,5, 吴美蓉1,2,3, 张晗1,2,3, 李霖1,2,3, 张磊4,5
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1.天津中医药大学组分中药国家重点实验室, 天津 301617;2.天津中医药大学方剂学教育部重点实验室, 天津 301617;3.天津中医药大学中医药研究院, 天津 301617;4.天津中医药大学第一附属医院, 天津 300381;5.国家中医针灸临床医学研究中心, 天津 300381
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| 摘要: |
| 神经病理性疼痛是一种由周围和/或中枢神经损伤引起的慢性疼痛状态，小胶质细胞和星形胶质细胞介导的神经炎症在慢性疼痛的产生和维持中发挥重要作用。小胶质细胞参与星形胶质细胞促炎介质的产生，星形胶质细胞参与小胶质细胞炎症因子的分泌，诱发其产生促炎作用，两者串扰可显著影响神经炎症的发展。文章通过查阅研读相关文献，总结了小胶质细胞-星形胶质细胞串扰在神经病理性疼痛中发挥的作用以及中医药的研究现状，以期为神经病理性疼痛的机制及治疗提供新靶点。 |
| 关键词: 神经病理性疼痛 星形胶质细胞 小胶质细胞 串扰 中医药 |
| DOI：10.11656/j.issn.1672-1519.2023.07.21 |
| 分类号:R741.02 |
| 基金项目:国家自然科学基金项目（82004331）。 |
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| Mechanism of microglia-astrocyte crosstalk in neuropathic pain and the research progress on traditional Chinese medicine |
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CHEN Yuzhao1,2,3,4,5, WU Meirong1,2,3, ZHANG Han1,2,3, LI Lin1,2,3, ZHANG Lei4,5
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1.State Key Laboratory of Components of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;3.Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;4.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China;5.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
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| Abstract: |
| Neuropathic pain is a chronic pain state caused by peripheral and/or central nerve injury. Neuroinflammation mediated by microglia and astrocytes whitch play an important role in the generation and maintenance of chronic pain. Microglia participate in the production of astrocyte pro-inflammatory mediators，and astrocytes take part the secretion of microglial inflammatory factors，inducing them to produce pro-inflammatory effects，their crosstalk can significantly affect the development of neuroinflammation. This article summarized the role of microglia-astrocyte crosstalk in neuropathic pain and the research status of traditional Chinese medicine by reviewing and studying relevant literature，in order to provide new target for the mechanism and treatment of neuropathic pain. |
| Key words: neuropathic pain astrocytes microglia crosstalk traditional Chinese medicine |
